Xanthines, optionally incorporated in liposomes, for promoting skin or hair pigmentation
AssigneeLvmh Recherche
InventorsFrederic Bonte, Marc Dumas, Alain Meybeck, Christian Marechal
Life of this patent
Estimating the term…
Abstract
A method of treating skin or hair for promoting pigmentation wherein a xanthine component, in an amount effective to promote pigmentation, is incorporated in liposomes or hydrated lipidic lamellar phases.
Claims43
A method of treating the skin or hair for promoting pigmentation, said method comprising applying to said skin or hair to be pigmented, in an amount effective to producing pigmentation, at least one xanthine component incorporated in liposomes or in hydrated lipidic lamellar phases,
- (a) where in the xanthine has the formula (I) below:
- ##STR3## in which:
- R.sub.1 and R.sub.2 are identical or different and are each a hydrogen atom, a linear or branched alkyl radical having from 1 to 8 carbon atoms or a cyclo alkyl radical having from 3 to 8 carbons atoms, an alkenyl radical with a linear or branched chain having from 2 to 5 carbon atoms, an alkynyl radical having from 2 to 3 carbon atoms or an aralkyl radical having from 7 to 12 carbon atoms, said alkyl, alkenyl and aralkyl radicals being unsubstituted or substituted by one or more halogen atoms or by one or more groups--OR.sub.5 in which R.sub.5 is a hydrogen atom or an alkyl radical having from 1 to 6 carbon atoms,
- R.sub.3 is a hydrogen atom, an alkyl radical having from 1 to 4 carbon atoms or a benzyl radical, said alkyl radical being unsubstituted or substituted by heterocyclic radical morpholin-4-yl piperidin-1-yl radical or by one or more halogen atoms or hydroxyl groups, and
- R.sub.4 is a hydrogen or halogen atom, a linear or branched alkyl radical having 1 to 6 carbon atoms a cycloalkyl radical having 3-6 carbon atoms, radical being unsubstituted or substituted by one or more halogen atoms hydroxyl, methoxy, carbomethoxy or amino groups, or, R.sub.4 is the group:
- ##STR4## in which R.sub.6 and R.sub.7 independently are a hydrogen atom or an alkyl radical having from 1 to 6 carbon atoms, or, R.sub.6 and R.sub.7 form together with said nitrogen atom, a piperidin-1-yl, said alkyl radicals being unsubstituted or substituted by one or more halogen atoms or hydroxyl, methoxy., carbomethoxy or amino groups, or
- (b) a pharmaceutically or cosmetically acceptable salt of said xanthine of formula (I).
A method of treating the skin or hair for promoting pigmentation, said method comprising applying to said skin or hair to be pigmented, in an amount effective for producing pigmentation, at least one xanthine component incorporated in liposomes or in hydrated lipidic lamellar phases, wherein:
- (a) a xanthine of the formula (I) below:
- ##STR5## in which:
- R.sub.1 and R.sub.2 are identical or different and are each a hydrogen atom, a linear or branched alkyl radical having from 1 to 8 carbon atoms a cyclo alkyl radical having 3-8 carbon atoms, at least one R.sub.1 and R.sub.2 being a hydrogen atom, or
- (b) a pharmaceutically or cosmetically acceptable salt of said xanthine of formula (I).
A method of treating the skin or hair for promoting pigmentation, said method comprising applying to said skin or hair to be pigmented, in an amount effective for producing pigmentation, at least one xanthine component
- (a) wherein the xanthine is selected from the group consisting of:
- 1,8-dimethyl-3-isobutylxanthine,
- 7-benzyl-1,8-dimethyl-3-isobutylxanthine,
- 1-(2-hydroxyethyl)-3-isobutyl-8-methylxanthine,
- 1,8-dimethyl-3-(2- methyl-2-propenyl)xanthine,
- 3-(2,3-dibromopropyl)-1-ethyl-8-methylxanthine,
- 1,3-di(2-propenyl)-8-methylxanthine,
- 7-benzyl-8-bromo-3-isobutyl-1-methylxanthine,
- 8-ethyl-1-(2-hydroxyethyl)-3-isobutylxanthine,
- 8-hydroxymethyl-3-isobutyl-1-methylxanthine,
- 3-isobutyl-8-methoxymethyl-1-methylxanthine,
- 8-(2-carbomethoxyethyl)-3-isobutyl-1-methylxanthine,
- 3-isobutyl-1-methyl-8-tert-butylxanthine,
- 3-isobutyl-1-methyl-8-methylaminoxanthine,
- 1,3-dipropyl-8(piperidin-1-yl(xanthine)
- 8-cyclopropyl-1,3-dipropylxanthine,
- 8-cyclopentyl-1,3-dipropylxanthine,
- 8-cyclohexyl-1,3-dipropylxanthine,
- 1,3-dimethyl-8-phenylxanthine,
- 1,3-dipropyl-8-phenylxanthine,
- 8-(2-amino-4-chlorophenyl)-1,3-dipropylxanthine,
- 1,3-diethyl-7-methylxanthine,
- 1,3-dipropyl-7-methylxanthine,
- 7-chloromethyl-1,3-dimethylxanthine,
- 1,3-dimethyl-7-hydroxymethylxanthine,
- 1,3-dimethyl-7-(morpholin-4-yl-methyl)xanthine,
- 1,3,7-triethylxanthine,
- 3,7-diethyl-1-(2-propynyl)xanthine
- 7-(2-chloroethyl-1,3-dimethylxanthine
- 3-benzyl-1-methylxanthine,
- 3-isopentyl-1-methylxanthine,
- 1-methyl-3-(2-propenyl)xanthine,
- 1-methyl-3-(2-methyl-2-propenyl)xanthine,
- 3-butyl-1-methylxanthine,
- 1,3-diethylxanthine,
- 1-ethyl-3-propylxanthine,
- 3-butyl-1-ethylxanthine,
- 1-ethyl-3-(2-methyl-2-propenyl)xanthine,
- 3-cyclohexyl-1-ethylxanthine,
- 1-(2-hydroxyethyl)-3-isobutylxanthine,
- 1,3-dipropylxanthine,
- 1,3-di-(2-propenyl)xanthine,
- 1,3-dibutylxanthine,
- 3-ethyl-1-pentylxanthine,
- 1-benzyl-3-isobutylxanthine,
- 1-methylxanthine,
- 1-ethylxanthine,
- 1-propylxanthine,
- 1-butylxanthine,
- 3-methylxanthine,
- 3-propylxanthine,
- 3-butylxanthine, and
- 3-isobutylxanthine;
- or
- (b) a pharmaceutically or cosmetically acceptable salt of said xanthine under (a).
A method of treating the skin or hair for promoting pigmentation, said method comprising applying to said skin or hair to be pigmented, in an amount effective for producing pigmentation, at least one xanthine component wherein:
- (a) the xanthine has the formula (I) below:
- ##STR6## in which:
- R.sub.1 and R2 are different and are each a hydrogen atom, a linear or branched alkyl radical having from 1 to 8 carbon atoms or a cyclo-alkyl radical having 3 to 8 carbon atoms, one of R.sub.1 and R.sub.2 being a hydrogen atom, or
- (b) a pharmaceutically or cosmetically acceptable salt of xanthine of formula (I).
Dependencies are inferred from the claim text.