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US 5,470,567 AGranted
Synergistic skin depigmentation composition
AssigneeBristol-Myers Squibb Company
InventorsXina Nair, Kenneth M. Tramposch
Life of this patent
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Abstract
There is disclosed a synergistic composition and process for skin depigmentation with reduced irritation which does not employ a corticosteroid and which employs a substituted oxybenzene and a retinoid.
Claims8
A synergistic composition for skin depigmentation free of corticosteroid comprising:
- (a) 4-hydroxyanisole in an amount from about 0.1% to about 2% by weight;
- (b) a retinoid selected from the group consisting of all-trans retinoic acid in an amount from about 0.001% to about 0.1% by weight, (N-acetyl-4-aminophenyl) retinoate in an amount from about 0.001% to about 0.01%, and 11-cis, 13-cis-12-hydroxymethyl retinoic acid .delta.-lactone in an amount from about 0.001% to about 0.1% by weight;
- and
- (c) a dermatologically acceptable carrier.
1 more element
A method for skin depigmentation which comprises topically applying to the skin a synergistic composition free of corticosteroid which comprises:
- (a) 4-hydroxyanisole in an amount from about 0.1% to about 2% by weight;
- (b) a retinoid selected from the group consisting of all-trans retinoic acid in an amount from about 0.001% to about 0.1% by weight, (N-acetyl-4-amino-phenyl) retinoate in an amount from about 0.001% to about 0.01% by weight and 11-cis, 13-cis-12-hydroxymethyl retinoic acid .delta.-lactone in an amount from about 0.001% to about 0.1% by weight;
- and
- (c) a dermatologically acceptable carrier.
1 more element
Dependencies are inferred from the claim text.