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US 5,468,845 AGranted
Antibodies to osteogenic proteins
AssigneeStryker Corporation
InventorsHermann Oppermann, Engin Ozkaynak, Thangavel Kuberasampath, David C. Rueger
Life of this patent
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AssigneeStryker Corporation
InventorsHermann Oppermann, Engin Ozkaynak, Thangavel Kuberasampath, David C. Rueger
Estimating the term…
Disclosed are (1) osteogenic devices comprising a matrix containing substantially pure natural-sourced mammalian osteogenic protein; (2) DNA and amino acid sequences for novel polypeptide chains useful as subunits of dimeric osteogenic proteins; (3) vectors carrying sequences encoding these novel polypeptide chains and host cells transfected with these vectors; (4) methods of producing these polypeptide chains using recombinant DNA technology; (5) antibodies specific for these novel polypeptide chains; (6) osteogenic devices comprising these recombinantly produced proteins in association with an appropriate carrier matrix; and (7) methods of using the osteogenic devices to mimic the natural course of endochondral bone formation in mammals.
An isolated antibody having binding specificity for an epitope on a protein comprising an amino acid sequence selected from the group consisting of:
An isolated antibody having binding specificity for a protein comprising an amino acid sequence selected from the group consisting of:
An isolated antibody having binding specificity for a protein comprising an amino acid sequence selected from the group consisting of:
An isolated antibody having binding specificity for a protein comprising an amino acid sequence selected from the group consisting of:
An isolated antibody having binding specificity for an epitope on a protein comprising an amino acid sequence selected from the group consisting of:
Dependencies are inferred from the claim text.