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AssigneesDongkook Pharmaceutical Co., Ltd., Ki Beom Kwon
InventorsWon T. Cho, Wan S. Kim, Myung K. Kim, Jin K. Park, Hak R. Kim, Sang K. Rhee, A. G. Domracheva, T. B. Panichkina, L. A. Saburoba, L. M. Nobikoba, Y. E. Bartochevichi
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Disclosed herein are a novel strain of Streptomyces and a method for the production of aclacinomycins A, B, Y and aglycone thereof by cultivating the same. Streptomyces lavendofoliae DKRS (KCTC 0092BP) of the present invention is capable of producing aclacinomycins A, B, Y and aglycone with higher yield. Further, it is possible to selectively produce aclacinomycin A or Y by adjusting pH of the cultured broth of Streptomyces lavendofoliae DKRS to 4.4 or 4.6 with acetate buffer or hydrochloric acid, respectively.
A S. lavendofoliae DKRS cell culture having the Accession No. KCTC 0092BP, and being capable of expressing a product selected from the group consisting of aclacinomycins A, B, and Y, and aglycones thereof.
Dependencies are inferred from the claim text.