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US 5,468,623 AGranted
Method of converting big endothelin-1 to endothelin-1 with human apolipoprotein B
AssigneeNisshin Flour Milling Co., Ltd.
InventorsTatsuya Ohwaki, Hiroshi Sakai
Life of this patent
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Abstract
A method for converting big endothelin-1 to endothelin-1 by contacting big endothelin-1 with a commercially available preparation of apolipoprotein B is presented. The apolipoprotein B itself has the converting enzyme activity.
Claims1
A method of converting big endothelin-1 to endothelin-1 comprising:
- contacting said big endothelin-1 with isolated, purified human apolipoprotein B having a proteolytic activity for cleaving said big endothelin-1 to produce said endothelin-1.
Dependencies are inferred from the claim text.