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US 5,466,823 AGranted
Substituted pyrazolyl benzenesulfonamides
AssigneeG.D. Searle & Co.
InventorsJohn J. Talley, Thomas D. Penning, Paul W. Collins, Donald J. Rogier, Jr., James W. Malecha, Julie M. Miyashiro, Stephen R. Bertenshaw, Ish K. Khanna, Matthew J. Graneto, Roland S. Rogers, Jeffery S. Carter
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Abstract
A class of pyrazolyl benzenesulfonamide compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by Formula I: ##STR1## or a pharmaceutically-acceptable salt thereof.
Claims13
A compound of Formula I ##STR44## wherein R.sup.1 is sulfamyl;
- wherein R.sup.2 is haloalkyl;
- wherein R.sup.3 is selected from hydrido, and alkyl;
- and
- wherein R.sup.4 is selected from aryl, cycloalkyl, and cycloalkenyl;
- wherein R.sup.4 is optionally substituted at a substitutable position with one or more radicals selected from halo, alkylthio, alkylsulfinyl, alkyl, alkylsulfonyl, cyano, carboxyl, alkoxycarbonyl, amido, N-monoalkylamido, N-monoarylamido, N,N-dialkylamido, N-alkyl-N-arylamido, haloalkyl, hydroxyl, alkoxy, hydroxyalkyl, haloalkoxy, sulfamyl, N-alkylsulfamyl, amino, N-alkylamino, N,N-dialkylamino, heterocyclic, nitro and acylamino;
- or a pharmaceutically-acceptable salt thereof.
3 more elements
A compound of Formula II ##STR45## wherein R.sup.2 is lower haloalkyl;
- wherein R.sup.3 is hydrido;
- and
- wherein R.sup.4 is selected from aryl, cycloalkyl, and cycloalkenyl;
- wherein R.sup.4 is optionally substituted at a substitutable position with one or more radicals selected from halo, lower alkylthio, lower alkylsulfonyl, cyano, nitro, lower haloalkyl, lower alkyl, hydrido, lower alkoxy, lower haloalkoxy, sulfamyl, heterocyclic and amino;
- or a pharmaceutically-acceptable salt thereof.
2 more elements
Dependencies are inferred from the claim text.