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US 5,466,806 AGranted
Processes for preparing substituted 1,3-oxathiolanes with antiviral properties
AssigneeBioChem Pharma Inc.
InventorsBernard Belleau, deceased, Tarek Mansour, Allan Tse, Colleen A. Evans, Haolun Jin, Boulos Zacharie, Nghe Nguyen-Ba
Life of this patent
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Abstract
Disclosed are processes for preparing compounds of the formula (I) and pharmaceutically acceptable salts or esters thereof: ##STR1## wherein R.sub.2 is a purine or pyrimidine base or an analogue or derivative thereof; and Z is S, S.dbd.O or SO.sub.2. The invention also relates to intermediates of use in the preparation of these compounds.
Claims8
A process for preparing a compound of formula (XIII):
- ##STR43## comprising the step of reacting a mercaptoacetaldehyde with a compound having the formula R.sub.w OCH.sub.2 CHO under neutral or basic conditions, wherein R.sub.w is hydrogen or a hydroxyl protecting group.
Dependencies are inferred from the claim text.