US 5,466,463 A · Viracidal, bactericidal and spermicidal vaginal suppository

Abstract

A vaginal suppository or other type of vaginal pessary such as cream, foam or ointment, which contains as its active ingredients at least one pharmaceutically acceptable, topically safe antimicrobial agent, such as an agent selected from the group of benzalkonium chloride, cetylpyridinium chloride, chlorhexidine gluconate and povidone iodine, imidiazolidinyl urea and diazolidinyl urea and a viable colony of micro-encapsulated lactobacilli bacteria. The viable lactobacilli are included in the suppository in micro encapsulated form, which protects the bacteria during storage of the suppository from the action of the bacteriocidal agent. When exposed to the vaginal milieu the micro encapsulation breaks down sufficiently to release the lactobacili bacteria. The lactobacilli bacteria serve to maintain or re-establish a healthy lactobacilli based flora on the vaginal wall, and excrete hydrogen peroxide and other bactericidins which suppress abnormal flora conditions that promote infections.

Claims35

Dependent claims

A vaginal pessary comprising:

an effective amount of a pharmaceutically acceptable, topically usable antimicrobial agent;
at least approximately 10.sup.3 viable bacteria of the lactobacillus acidophilus species or of its lactobacillus rhamnosus variant, said bacteria being micro encapsulated whereby the bacteria stay viable during storage of the pessary in spite of presence of the antimicrobial agent, the substance providing the encapsulating coating for the bacteria being such that it releases bacteria upon prolonged exposure to moisture in the vaginal environment, and
a pharmaceutically acceptable excipient thoroughly admixed with the antimicrobial agent and the micro encapsulated bacteria.

A vaginal suppository comprising:

an effective amount of a pharmaceutically acceptable, topically usable antimicrobial agent selected from the group consisting of benzalkonium chloride in the amount of 12 to 3000 mg, methylbenzethonium chloride in the amount of 12 to 3000 mg, cetyl pyridinium chloride in the amount of 25 to 4000 mg, alkyltrimethylammonium bromides in the amount of 25 to 4000 mg, chlorhexidine gluconate in the amount of 10 to 2000 mg, and povidone iodine in the amount of 25 to 5000 mg;
10 to 1000 mg of imidiazolidinyl urea;
10 to 1000 mg of diazolidinyl urea;
a spermicidal agent selected from the group consisting of 50 to 500 mg of nonoxynol 9, and 50 to 500 mg of octoxynol 9;
40 to 120 mg ascorbic acid;
an effective amount of a pharmaceutically acceptable buffer system that buffers the pH of the suppository in the range of 4.3 to 4.5;
at least approximately 10.sup.3 viable bacteria of the Lactobacillus acidophilus species or of its Lactobacillus rhamnosus variant, said bacteria being micro encapsulated whereby the bacteria stay viable during storage of the suppository in spite of presence of the antimicrobial agents, the substance providing the encapsulating coating for the bacteria being such that it releases bacteria upon prolonged exposure to moisture in the vaginal environment, and
a pharmaceutically acceptable excipient thoroughly admixed with the antimicrobial agent and the micro encapsulated bacteria.

5 more elements

Dependencies are inferred from the claim text.

Viracidal, bactericidal and spermicidal vaginal suppository

Life of this patent

Viracidal, bactericidal and spermicidal vaginal suppository

Life of this patent

Abstract

Claims35