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US 5,464,933 AGranted
Synthetic peptide inhibitors of HIV transmission
AssigneeDuke University
InventorsDani P. Bolognesi, Thomas J. Matthews, Carl T. Wild
Life of this patent
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Abstract
The present invention relates to peptides which exhibit potent anti-retroviral activity. The peptides of the invention comprise DP-178 (SEQ ID:1) ptides corresponding to amino acids 638 to 673 of the HIV-1.sub.LAI gp41 protein, and fragments, analogs and homologs of DP-178. The invention further relates to the uses of such peptides as inhibitory of human and non-human retroviral, especially HIV, transmission to uninfected cells.
Claims19
A peptide having a formula selected from the group consisting of:
- X-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-Z ( SEQ ID:
- 1)
- X-YTNTIYTLLEESQNQQEKNEQELLELDKWASLWNWF-Z (SEQ ID NO:3)
- X-YTGIIYNLLEESQNQQEKNEQELLELDKWANLWNWF-Z (SEQ ID NO:4)
- X-YTSLIYSLLEKSQIQQEKNEQELLELDKWASLWNWF-Z (SEQ ID NO:5)
- X-LEANISKSLEQAQIQQEKNMYELQKLNSWDIFGNWF-Z (SEQ ID NO:6)
- and
- X-LEANISQSLEQAQIQQEKNMYELQKLNSWDVFTNWL-Z (SEQ ID NO:7),
- in which:
- amino acid residues are presented by the single-letter code;
- X comprises an amino group, an acetyl group, a 9-fluorenylmethoxy-carbonyl group, a hydrophobic group, or a macromolecule carrier group;
- Z comprises a carboxyl group, an amido group, a hydrophobic group, or a macromolecular carrier group.
9 more elements
Dependencies are inferred from the claim text.