Pharmaceutical tablets releasing the active substance after a definite period of time
AssigneeJagotec AG
InventorsUbaldo Conte, Aldo La Manna, Lauretta Maggi
Life of this patent
Estimating the term…
Abstract
Pharmaceutical tablets releasing the active substance after a definite period of time, consisting of: a core containing the active substance and polymeric substances which swell and/or gel and/or erode on contact with water or with aqueous liquids; a layer applied externally to said core, suitable to prevent the immediate release of the active substance contained in the core and to allow the release of said active substance after a definite period of time, consisting of natural and/or synthetic polymeric materials of the class of the hydrophilic polymers which erode and/or gel and/or dissolve in an aqueous medium; a possible gastroresistant and enterosoluble coating.
Claims15
Pharmaceutical tablet for oral administration suitable to release the active substance after a definite period of time, consisting essentially of:
- a core containing the active substance to be released in the gastric or intestinal tract, a polymeric substance which swells and/or gels and/or erodes on contact with water or aqueous liquids and is selected from the group consisting of hydroxypropylmethylcellulose having a methoxyl content of 22.1% and a viscosity of 15,000 centipoises, crosslinked polyvinylpyrrolidone, crosslinked sodium carboxymethylcellulose, potassium methacrylate-divinyl-benzene copolymer, polyvinylalcohols and beta cyclodextrin and adjuvants and excipients;
- a layer applied externally to said core by a compression process said layer being suitable to allow the release of the active substance contained in the core after a definite period of time and being selected from the group consisting of hydroxypropylmethylcellulose having a methoxyl content of 22.1 and a viscosity of 4,000 centipoises, carboxy vinyl polymers, glucans, mannans, xanthans and carboxymethylcellulose and adjuvants and excipients;
- wherein said layer is applied externally to said core and has a thickness of 0.2-4.5 mm which allows the release of said active substance in said core after contact with water or an aqueous liquid for a period of 2 to 3 hours.
Pharmaceutical tablet for oral administration suitable to release a peptide drug selected from the group consisting of insulin, calcitonin and somatostatin after a definite period of time, said tablet consisting of:
- core containing a peptide drug selected from the group consisting of insulin, calcitonin and somatostatin, a polymeric substance which swells and/or gels and/or erodes on contact with water or aqueous liquids and is selected from the group consisting of hydroxypropylmethylcellulose having a methoxyl content of 22.1% and a viscosity of 15,000 centipoises, crosslinked polyvinylpyrrolidone, crosslinked sodium carboxymethylcellulose, potassium methacrylate-divinyl-benzene copolymers, polyvinylalcohols and beta cyclodextrin and adjuvants and excipients;
- a layer applied externally to said core by a compression process said layer being suitable to allow the release of said peptide drug contained in the core after a definite period of time and being selected from the group consisting of hydroxypropylmethylcellulose having a methoxyl content of 22.1 and a viscosity of 4,000 centipoises, carboxy vinyl polymers, glucans, mannans, xanthans and carboxymethylcellulose and adjuvants and excipients;
- wherein said layer is applied externally to said core and has a thickness of 1.0-1.50 mm which allows the release of said active substance in said core after contact with water or an aqueous liquid for a period of 2 to 3 hours.
Pharmaceutical tablet for oral administration suitable to release the active substance after a definite period of time, consisting essentially of:
- a core containing the active substance to be released in the gastric or intestinal tract, a polymeric substance which swells and/or gels and/or erodes on contact with water or aqueous liquids and is selected from the group consisting of hydroxypropylmethylcellulose having a methoxyl content of 22.1% and a viscosity of 15,000 centipoises, crosslinked polyvinylpyrrolidone, crosslinked sodium carboxymethylcellulose, potassium methacrylate-divinyl-benzene copolymer, polyvinylalcohols and beta cyclodextrin and adjuvants, and excipients;
- a layer applied externally to said core by a compression process said layer being suitable to allow the release of the active substance contained in the core after a definite period of time and being selected from the group consisting of hydroxypropylmethylcellulose having a methoxyl content of 22.1 and a viscosity of 4,000 centipoises, carboxyl vinyl polymers, glucans, mannans, xanthans and carboxymethylcellulose and adjuvants and excipients;
- wherein said layer is applied externally to said core and has a thickness of 0.2-4.5 mm which allows the release of said active substance in said core after contact with water or an aqueous liquid for a period of 2 to 3 hours wherein said pharmaceutical tablet has a gastroresistant and enterosoluble coating which consists of polymeric materials selected from the group consisting of cellulose acetophthalate, cellulose acetopropionate, cellulose trimellitate, acrylic polymers, acrylic copolymers, methacrylic polymers and methacrylic copolymers.
Dependencies are inferred from the claim text.