Method for the preparation of D-chiro-inositol
AssigneeAbbott Laboratories
InventorsDavid A. Riley, Steven A. Chamberlin, Ashok V. Bhatia
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Abstract
A method for the preparation of D-chiro-inositol from kasugamycin, comprising the steps of: (a) reacting kasugamycin with an acetylating agent to form a crude hexa-acetate intermediate; (b) purifying the crude intermediate to form purified hexa-acetate intermediate; (c) deacetylating the purified intermediate to form D-chiro-inositol; and (d) isolating the D-chiro-inositol. The method permits efficient, large-scale preparation of D-chiro-inositol without the need for extensive chromatographic purification of the final D-chiro-inositol product.
Claims27
A method for the preparation of D-chiro-inositol from kasugamycin, comprising the steps of:
- (a) reacting kasugamycin with an acetylating agent to form a crude hexa-acetate;
- (b) purifying the crude hexa-acetate to form purified hexa-acetate;
- (c) deacetylating the purified hexa-acetate to form D-chiro-inositol;
- and
- (d) isolating the D-chiro-inositol.
Dependencies are inferred from the claim text.