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US 5,462,927 AGranted
Peptides aiding nerve regeneration
AssigneeThe Administrators of the Tulane Educational Fund
InventorsJacques-Pierre Moreau, David H. Coy
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Abstract
Biologically active peptides are disclosed of the formula: A.sup.1 --A.sup.2 --A.sup.3 --A.sup.4 --Phe--Arg--TrP--A.sup.5, or a pharmaceutically acceptable salt thereof; A.sup.1 is H or acetyl; A.sup.2 is Ala, or D--Ala; A.sup.3 is Glu or Gln; and A.sup.4 is His or Tyr; A.sup.5 is NH.sub.2, Gly--NH.sub.2, or D--Ala--NH.sub.2. Pharmaceutical compositions containing these peptides are capable of promoting nerve regeneration and increasing muscle mass or preventing muscle atrophy following an injury.
Claims12
A peptide of the formula:
- A.sup.1 --A.sup.2 --A.sup.3 --A.sup.4 --Phe--Arg--Trp--A.sup.5
- wherein A.sup.1 is H or acetyl;
- A.sup.2 is D--Ala;
- A.sup.3 is Glu or Gln;
- and
- A.sup.4 is His or Tyr;
- A.sup.5 is Gly--NH.sub.2 ;
- or a pharmaceutically acceptable salt thereof.
5 more elements
Dependencies are inferred from the claim text.