Substance transfer system for topical application

A topically applicable substance transfer device for transdermal or topical transfer of substances to and from a living body, said device having an inner surface for body contact, and further comprising:

• a layer of skin compatible adhesive having an inner surface for body contact;
• a plurality of channels extending through the layer of adhesive, each said channel having an inner opening at the inner surface of the device substantially completely surrounded by adhesive;
• substance depots in liquid communication with the inner openings of at least some of said channels and adapted to transfer substance to and from said openings, said substance depots having inner surfaces which protrude beyond the inner surface of the adhesive layer;
• said inner surface of the device being comprised of discrete areas constituted respectively by the inner openings of said channels and by the inner surface of said adhesive layer;
• and said channels being lined with barrier material to impede diffusion between the substance depots and the adhesive.