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US 5,462,740 AGranted
Rectally-administered, epileptic-seizure-inhibiting composition
AssigneeAthena Neurosciences, Inc.
InventorsKenneth L. Evenstad, Victoria A. O'Neill, Thomas R. Gorham
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Abstract
This invention provides a rectally administered composition for inhibiting epileptic seizure and to its methods of use. The composition contains, in a suitable solvent, an anti-epileptic agent for inhibiting epileptic seizure, a buffer for maintaining pH, and a thickener for imparting a viscosity to the composition effective for rectal administration by injection to a patient in epileptic seizure.
Claims8
A viscous, epileptic-seizure-inhibiting composition comprising:
- (a) about 0.1-2.5 wt-% of the total composition of an anti-epileptic agent;
- (b) a buffer system in an amount effective to maintain the pH of the composition at about 5.5-7.5;
- (c) about 1-10 wt-% of a cellulose ether thickener to impart a viscosity to the composition so that it is suitable for administration by rectal injection to a human patient;
- and
- (d) about 25-95 wt-% solvent.
2 more elements
A viscous, epileptic-seizure-inhibiting composition comprising:
- (a) about 0.25-0.75 wt-% diazepam;
- (b) a buffer system in an amount effective to maintain the pH of the composition at about 5.5-7.5;
- (c) about 1-10 wt-% cellulose ether thickener;
- (d) about 25-75 wt-% of a non-toxic water-miscible organic solvent;
- and
- (e) the balance, water.
3 more elements
Dependencies are inferred from the claim text.