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US 5,460,830 AGranted
Biochemically active agents for chemical catalysis and cell receptor activation
AssigneeThe Regents of the University of California
InventorsNir Kossovsky, Edward Sponsler, Andrew Gelman, Samir Rajguru
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Abstract
A biologically active composition made up of core particles or surfaces which are coated with a layer which is designed to allow attachment of biochemically reactive pairs (BRP's) without denaturing the BRP to the microparticles. BRP's which may be attached include ligand-receptor pairs, enzyme-substrate pairs, drug-receptor pairs, catalyst-reactant pairs, toxin-ligand pairs, absorbant-absorbate pairs and adsorbant-adsorbate pairs.
Claims10
A biochemically active composition of matter comprising:
- an article having a surface selected from the group consisting of a metal, metal alloy, polymer, ceramic, glass or intermetallic;
- a coating located on said surface which provides a coated surface said coating consisting essentially of a substance which provides a threshold surface energy to said surface which is sufficient to bind biochemically reactive pairs without denaturing said pairs and said substance being selected from the group consisting of short chain carbohydrates, polymeric carbohydrates, nitrocellulose, pyridoxyl-5-pyrophosphate, thiamine pyrophosphate, uridine-diphosphate-glucose, glucose-1-phosphate, adenosine, nicotinamide-adenine-diphosphate, citrate, fumarate, succinate, isocitrate, oxaloacetate and malate;
- and
- at least one biochemically reactive pair bound to said coated surface wherein said biochemically reactive pair bound to said coated surface is not denatured to thereby provide said biochemically active composition.
1 more element
Dependencies are inferred from the claim text.