Method for fixing tissues and cells for analysis using oxazolidine compounds
AssigneeStreck Laboratories, Inc.
InventorWayne L. Ryan
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Abstract
A method and composition for fixing and stabilizing tissues, cells, and cell components such that the antigenic sites are preserved for a useful period of time. The fixative employs compounds that are less toxic, non-flammable, and that stabilize the cell with minimal damage to and alteration of the cell morphology. In particular, the cell antigenic sites are left intact so that studies with monoclonal antibodies may be conducted. The invention also discloses a method for developing a positive control for test reagents and for test instrumentation.
Claims10
In a method for the analysis of a biological material wherein said biological material is a cell or tissue preserved by a fixing or stabilizing solution, the improvement comprising:
- treating said biological material with a fixative which comprises at least one oxazolidine in an amount sufficient to fix said biological material;
- and analyzing said preserved biological material.
Dependencies are inferred from the claim text.