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US 5,459,030 AGranted
Synthetic media compositions for inactivating bacteria and viruses in blood preparations with 8-methoxypsoralen
AssigneeSteritech, Inc.
InventorsLily Lin, Laurence Corash
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Abstract
Synthetic media formulations are disclosed for use with blood preparations intended for in vivo use, including synthetic media formulations to be employed in conjunction with the photodecontamination of platelets using 8-methoxypsoralen.
Claims14
A synthetic platelet storage medium, comprising an aqueous solution of:
- 45-100 mM sodium chloride;
- 4-5 mM potassium chloride;
- 10-15 mM sodium citrate;
- 20-27 mM sodium acetate;
- approximately 2 mM glucose;
- 20-30 mM mannitol;
- approximately 20 mM sodium phosphate;
- 2-3 mM magnesium chloride;
- and
- 8-methoxypsoralen at a concentration between approximately 2 ug/ml and its maximum solubility in water.
7 more elements
A synthetic platelet storage medium, comprising an aqueous solution of:
- 45-100 mM sodium chloride;
- 4-5 mM potassium chloride;
- 10-15 mM sodium citrate;
- 20-27 mM sodium acetate;
- approximately 2 mM glucose;
- approximately 20 mM sodium phosphate;
- - 3mM magnesium chloride;
- plasma at a concentration of between 8 and 25% by volume;
- and
- 8-methoxypsoralen at a concentration between approximately 2 .mu.g/ml and its maximum solubility in water.
7 more elements
A synthetic platelet storage medium, comprising an aqueous solution of:
- sodium chloride at a concentration of approximately 100 mM;
- potassium chloride at a concentration of approximately 4 mM;
- sodium citrate at a concentration of approximately 10 mM;
- sodium acetate at a concentration of approximately 20 mM;
- glucose at a concentration of approximately 2 mM;
- sodium phosphate at a concentration of approximately 20 mM;
- magnesium chloride at a concentration of approximately 2 mM;
- human plasma at a concentration of between 8 and 25% by volume;
- and
- 8-methoxypsoralen at a concentration between approximately 2 .mu.g/ml and 30 .mu.g/ml.
7 more elements
Dependencies are inferred from the claim text.