Controlled release tablet formulation
AssigneeAndrx Pharmaceuticals, Inc.
InventorsChih-Ming Chen, Charles S. L. Chiao, Jose Suarez
Life of this patent
Estimating the term…
Abstract
The present invention is directed to a controlled release dosage form which may be made using an osmotic core which contains a drug containing phase which includes a water swellable component and a continuous coating which comprises a major amount of a water resistant polymer and a minor amount of a non-toxic, water soluble, pharmaceutically acceptable compound.
Claims14
A controlled release dosage pharmaceutical tablet which comprises:
- (a) an osmotic core which consists essentially of a drug and a water swellable component selected from the group consisting of hydroxypropylmethyl cellulose and polyethylene oxide in admixture with said drug;
- and
- (b) a coating which comprises a water resistant polymer and a minor amount of a non-toxic, water soluble, pharmaceutically acceptable compound in an amount which is sufficient to dissolve in gastrointestinal fluid and form a plurality of micropores in the outside of said tablet said water resistant polymer which are microporous to the passage of gastrointestinal fluid.
A controlled release dosage pharmaceutical tablet which comprises:
- (a) an osmotic core which consists essentially of a drug, a water swellable component selected from the group consisting of hydroxypropylmethyl cellulose and polyethylene oxide in admixture with said drug, an osmotic agent;
- and
- (b) a coating which comprises a water resistant polymer and a minor amount of a non-toxic, water soluble, pharmaceutically acceptable compound in an amount which is sufficient to dissolve in gastrointestinal fluid and form a plurality of micropores in the outside of said tablet said water resistant polymer which are microporous to the passage of gastrointestinal fluid.
A controlled release pharmaceutical dosage tablet which comprises:
- (a) an osmotic core which consists essentially of a drug in admixture with, an osmotic amount of sodium chloride and as a swellable component polyethylene oxide;
- and
- (b) a coating which comprises a cellulose acetate, triacetin and a minor amount of sodium chloride in an amount which is sufficient to dissolve in gastrointestinal fluid and form a plurality of micropores to the outside of said tablet which render said water resistant polymer microporous to the passage of gastrointestinal fluid.
A controlled release dosage pharmaceutical tablet which consists essentially of:
- (a) an osmotic core which consists of a drug and a water swellable component selected from the group consisting of hydroxypropylmethyl cellulose and polyethylene oxide in admixture with said drug;
- and
- (b) a coating which comprises a water resistant polymer and a minor amount of a non-toxic, water soluble, pharmaceutically acceptable compound in an amount which is sufficient to dissolve in gastrointestinal fluid and form a plurality of micropores in the outside of said tablet said water resistant polymer which are microporous to the passage of gastrointestinal fluid.
Dependencies are inferred from the claim text.