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US 5,457,207 AGranted
Spirovesamicols
AssigneeRegents of the University of Minnesota
InventorsSimon M. N. Efange, Stanley M. Parsons
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Abstract
The compounds are vesamicol (hydroxylated phencyclidine (PCP) isomer trans-2-(4-phenyl-piperidino)cyclohexanol) derivatives with anticholinergic properties termed herein "spirovesamicols" which are spirofused piperidines. The compounds bind to the vesamicol receptor, a site on the cholinergic synaptic vesicle, which is associated with the vesicular transporter of acetylcholine.
Claims1
A vesamicol receptor ligand compound selected from the structural formula:
- ##STR1## wherein X is --CH.dbd.CH--, --CH.sub.2 CH.sub.2 --, --(CH.sub.2).sub.3, --CY.dbd.CZ--, --CHY--CHZ--;
- Y is H, halogen;
- Z is H, halogen;
- R is H or halogen;
- and
- W is an aliphatic hydrocarbon group containing between 0 and 4 carbons.
3 more elements
Dependencies are inferred from the claim text.