Method for making a bioerodible material for the sustained release of a medicament and the material made from the method

A method for forming a biodegradable matrix suitable for use in a sustained time release particle, said method comprising the steps of:

• selecting a bioerodible polymer PLGA for use;
• adjusting the density of the bioerodible polymer PLGA;
• and
• grinding and sorting the density adjusted bioerodible polymer PLGA to select density adjusted bioerodible polymer PLGA particles of a predetermined size,
• wherein said density adjusted bioerodible polymer PLGA particles are bioerodible at a rate which is determined by said adjusted density and said predetermined size.

A sustained time release particle for the release of a medicament made by a method comprising the steps of:

• selecting a medicament for use;
• selecting a bioerodible polymer PLGA for use;
• adjusting the density of the bioerodible polymer PLGA;
• grinding and sorting the density adjusted bioerodible polymer PLGA to select density adjusted bioerodible polymer PLGA particles of a predetermined size, said particles having pores;
• dissolving the medicament in a solvent in which the bioerodible polymer PLGA is not soluble to form a medicament solution;
• mixing the selected density adjusted bioerodible polymer PLGA particles into said solution of the medicament;
• applying a vacuum to the suspension of said solution of medicament and density adjusted bioerodible PLGA polymer particles to remove air from said pores of said density adjusted bioerodible polymer PLGA;
• releasing said vacuum to load said solution of medicament into said particles;
• and
• isolating the density adjusted bioerodible polymer PLGA particles which are loaded with said medicament.

A method for forming a bioerodible sustained time release material for the continuous release of a medicament, said method comprising the steps of:

• selecting a medicament in solid form for use;
• selecting a bioerodible polymer PLGA for use;
• adjusting the density of the bioerodible polymer PLGA;
• grinding and sorting the density adjusted bioerodible polymer PLGA to select density adjusted bioerodible polymer PLGA particles of a predetermined size;
• mixing said medicament in solid form and said selected density adjusted bioerodible polymer PLGA particles;
• and
• extruding said mixture of medicament-loaded selected density adjusted bioerodible polymer PLGA into a rod using a predetermined temperature and pressure,
• wherein said density adjusted bioerodible polymer PLGA rod is bioerodible at a rate which is determined by said adjusted density and said predetermined size of said selected density adjusted bioerodible polymer PLGA particles.

A bioerodible sustained time release material for the continuous release of a medicament formed from a method comprising the steps of:

• selecting a medicament in solid form for use;
• selecting a bioerodible polymer PLGA for use;
• adjusting the density of the bioerodible polymer PLGA;
• grinding and sorting the density adjusted bioerodible polymer PLGA to select density adjusted bioerodible polymer PLGA particles of a predetermined size;
• mixing said medicament in solid form and said selected density adjusted bioerodible polymer PLGA to produce a medicament-loaded selected density adjusted bioerodible polymer PLGA;
• and
• extruding said mixture of medicament-loaded selected density adjusted bioerodible polymer PLGA into a rod using a predetermined temperature and pressure,
• wherein said density adjusted bioerodible polymer PLGA rod is bioerodable at a rate which is determined by said adjusted density and said predetermined size of said selected density adjusted bioerodible polymer PLGA particles.