N,N-disubstituted arylcycloalkylamines, the salts thereof, pharmaceutical compositions containing these compounds and the use thereof and processes for preparing them

A method of inhibiting cholesterol biosynthesis in a warm-blooded animal which comprises administering to said animal an effective amount of an N,N-disubstituted arylcycloalkylamine of formula I ##STR18## wherein n is the integer 1 or 2;

• m is the integer 0 or 1;
• A is a single bond, a straight-chained or branched C.sub.1-17 -alkylene group, a C.sub.2-17 alkenylene group or a C.sub.2-4 -alkynylene group;
• X is a carbonyl or sulphonyl group;
• R.sup.1 is a straight-chained or branched C.sub.1-5 -alkyl group;
• R.sup.2 is a straight-chained or branched C.sub.1-5 -alkyl group which may be substituted by one or two hydroxy groups, by an alkoxy or by an alkylcarbonyloxy group having 1 to 5 carbon atoms in the alkyl moiety, the alkyl moiety being straight-chained or branched, by an alkoxycarbonyloxy group, whilst the above-mentioned substituents may not be bound in position 1 of the alkyl group and two of these groups may not be bound to the same carbon atom, or by an aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, cyano or alkylcarbonyl group;
• R.sup.3, R.sup.4 and R.sup.5, which may be identical or different, each are a hydrogen atom or an alkyl group;
• R.sup.6 is a hydrogen atom, a straight-chained or branched C.sub.1-6 -alkyl group, a C.sub.3-6 -cycloalkyl group, an allyl or propargyl group or an optionally halogen-substituted benzyl group;
• R.sup.7 is a hydrogen atom, a C.sub.3-6 -cycloalkyl group, a phenyl group optionally substituted by an alkyl group, by one or two halogen atoms or by a trifluoromethyl group, or R.sup.7 is a naphthyl or tetrahydronaphthyl group or a thienyl group optionally substituted by a halogen atom or by an alkyl group;
• whilst A cannot be a single bond if X is a sulphonyl group and R.sup.7 is a hydrogen atom, and
• unless otherwise specified the above-mentioned alkyl and alkoxy moleties may each contain 1 to 3 carbon atoms and the above-mentioned halogen atoms may each be a fluorine, chlorine or bromine atom, or an enantiomer, diastereomer or physiologically acceptable salt thereof.