Aqueous antacids with calcium carbonate and magnesium salt
AssigneeMcNeil-PPC, Inc.
InventorsDouglas S. Beyerle, Gerard P. McNally
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Abstract
The present invention relates to an aqueous pharmaceutical suspension for oral use, and a method of preparation, having antacid and antiulcer properties which contains a therapeutically effective amount of calcium carbonate in combination with magnesium carbonate and/or magnesium trisilicate and a carboxylic acid pH adjusting agent.
Claims14
A method of preparing a stable aqueous antacid suspension for oral use having a pH of about 7.5 to about 8.5 of calcium carbonate in combination with a magnesium salt selected from the group consisting of magnesium carbonate, magnesium trisilicate and a mixture thereof as the sole active antacid component, which comprises in the order specified the steps of:
- (a) adding to water an effective antacid amount of particulate calcium carbonate and said magnesium salt, each in the particulate form of a micronized powder with 100% particle size distribution of about 0.1 to about 20 microns with mixing until the particulate material is completely wetted and dispersed;
- (b) adding to said dispersion with stirring an effective suspending amount of a thickening agent for a time sufficient to substantially coat said particulate material and to produce a suspension;
- and
- (c) adding to said suspension with stirring an effective pH adjusting amount of a carboxylic acid pH adjusting agent to provide a pH of about 7.5 to about 8.5 to the aqueous antacid suspension.
A method of preparing a stable aqueous antacid suspension for oral use with pH of about 8.0 to about 8.3 of calcium carbonate and magnesium carbonate as the sole active antacid component, which comprises in the order specified the steps of:
- (a) adding to water an effective antacid amount of particulate calcium carbonate and particulate magnesium carbonate, each in the form of a micronized powder with 100% particle size distribution of about 0.1 to about 20 microns with mixing until the particulate material is completely wetted and dispersed;
- (b) adding to said dispersion an effective suspending amount of xanthan gum or xanthan gum premixed with glycerin, with stirring for a time sufficient to substantially coat said particulate material and to provide a suspension;
- and
- (c) adding to said suspension with stirring an effective pH adjusting amount of tartaric acid to provide a pH of about 8.0 to about 8.3 to the final antacid suspension.
Dependencies are inferred from the claim text.