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US 5,455,030 AGranted
Immunotheraphy using single chain polypeptide binding molecules
AssigneeEnzon Labs Inc.
InventorsRobert C. Ladner, Robert E. Bird, Karl Hardman
Life of this patent
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Abstract
The invention pertains to a single polypeptide chain binding molecule which has binding specificity and affinity substantially similar to the binding specificity and affinity of the light and heavy chain aggregate variable region of an antibody, to genetic sequences coding therefor, and to recombinant DNA methods of producing such molecule and uses for such molecule.
Claims15
In an immunotherapeutic method which utilizes an antibody conjugated to a therapeutic agent, the improvement comprising using in the place of said antibody a single polypeptide chain binding molecule which comprises:
- (a) a first polypeptide comprising the antigen binding portion of the light chain variable region of an antibody;
- (b) a second polypeptide comprising the antigen binding portion of the heavy chain variable region of an antibody;
- and
- (c) at least one peptide linker linking said first and second polypeptides (a) and (b) into a single chain polypeptide having binding affinity for said antigen.
1 more element
Dependencies are inferred from the claim text.