Vitamin D3 Flourinated Analogs
AssigneeHoffman-La Roche Inc.
InventorsEnrico G. Baggiolini, deceased, Barbara J. Baggiolini, Shian-Jan Shiuey, Milan R. Uskokovic
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Abstract
Compounds of the formula ##STR1## wherein R is hydrogen, hydroxy, or fluorine, and X is H.sub.2 are useful as agents for the treatment of hyperproliferative disorders of the skin such as psoriasis, as agents for the treatment of cancer, such as, leukemia, and as agents for the treatment of sebaceous gland diseases, such as, acne and seborrheic dermatitis.
Claims8
A compound of the formula ##STR12## wherein R is hydrogen, hydroxy, or fluorine and X is H.sub.2.
The compound in accordance with claim 1, 26,26,26,27,27,27-hexafluoro-1.alpha., 25-dihydroxy-16-ene-23-yne-19-nor-cholecalciferol.
A pharmaceutical composition comprising an effective amount of a compound of the formula ##STR13## wherein R is hydrogen, hydroxy or fluoride, X is H.sub.2.
Dependencies are inferred from the claim text.