Pulmonary drug delivery system
AssigneeHong Kong University of Science and Technology R & D Corporation Limited
InventorsJeffrey T.-F. Wong, Michael S.-C. Tam
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Abstract
The present invention provides a method of improving the efficiency of absorption into the bloodstream of drugs delivered through the pulmonary route. The drug is mixed with surfactant, preferably a surfactant naturally produced by the lung. This method is found to enhance the absorption of pharmaceutical compositions, and in particular those comprising protein, eg insulin, or peptides, eg vasopressin.
Claims21
A pharmaceutical composition for the therapeutic systemic non-pulmonary treatment of humans or animals, comprising an effective amount of a pharmaceutically active agent mixed directly with pulmonary surfactant, said pharmaceutically active agent not being encapsulated in a liposome or a reverse micelle.
A method for the manufacture of a pharmaceutical composition for the systemic non-pulmonary treatment of humans or animals, comprising mixing directly an effective amount of a pharmaceutically active agent with a pulmonary surfactant, said pharmaceutically active agent not being encapsulated in a liposome or a reverse micelle.
A method for the therapeutic systemic non-pulmonary treatment of humans or animals comprising the pulmonary delivery of an effective amount of a pharmaceutically active agent mixed directly with a pulmonary surfactant, said pharmaceutically active agent not being encapsulated in a liposome or a reverse micelle.
A method for the therapeutic treatment of diabetes mellitus comprising the pulmonary delivery of a pharmaceutical composition comprising an effective amount of insulin mixed with natural lung surfactant, said insulin not being encapsulated in a liposome or a reverse micelle.
Dependencies are inferred from the claim text.