Cytotoxic compounds
AssigneePharmaMar, S.A.
InventorsJun-Ichi Tanaka, Tatsuo Higa, Khanit Suwanoborirux, C. W. Jefford, G. Bernardinelli, Dolores G. Gravalos
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Abstract
Compounds isolated from a marine sponge, and derivatives thereof, have the formulae: ##STR1## in which R.sup.1 is H or lower alkyl; R.sup.2 is OH or CH.sub.3 ; R.sup.3 is OH or CH.sup.3, and R.sup.4 H or MPTA. The compounds have antitumor and antiviral activity. The invention also provides pharmaceutical compositions containing the compounds and methods of treatment employing them.
Claims18
A compound having the formula I:
- ##STR4## wherein R.sup.1 is H or lower alkyl, R.sup.2 is OH or CH.sub.3 and R.sup.3 is OH or CH.sub.3 ;
- or a pharmaceutically acceptable salt thereof.
A compound having the formula II:
- ##STR5## wherein R.sup.1 is H or a lower alkyl, R.sup.2 is OH or CH.sub.3, R.sup.3 is OH or CH.sub.3 and R.sup.4 is H or .alpha.-methoxy-.alpha.-(trifluoromethyl)phenylacetyl;
- or a pharmaceutically acceptable salt thereof.
The substantially pure compound mycaperoxide A, having the following chemical structure:
- ##STR6##
The substantially pure compound mycaperoxide B, having the following chemical structure:
- ##STR7##
Dependencies are inferred from the claim text.