Analyte separation process and apparatus
AssigneeMIMS Technology Development Co.
InventorsRobert G. Cooks, Scott J. Bauer
Life of this patent
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Abstract
Described are preferred processes and apparatuses for treating samples so as to form conditioned samples for analysis, such as by a mass spectrometer. The apparatuses and processes of the invention include the use of both a membrane separator and a jet separator. This combination of separation techniques results in dramatic and unexpected increases in detection limits.
Claims14
A device for treating a sample for introduction into a mass spectrometer, comprising:
- a membrane separator device adapted to treat a crude analyte-containing sample to selectively pass the analyte through a membrane to form a first conditioned sample enriched in the analyte relative to the crude sample;
- a jet separator device fluidly coupled to the membrane separator device to receive said first conditioned sample, and adapted to treat the first conditioned sample to form a second conditioned sample enriched in the analyte relative to the first conditioned sample.
A method for treating a crude analyte-containing sample for introduction into a mass spectrometer, comprising:
- treating said crude sample with a membrane separator device to pass the analyte through a membrane so as to form a first conditioned sample enriched in the analyte relative to the crude sample;
- and
- treating said first conditioned sample with a jet separator device so as to form a second conditioned sample enriched in the analyte relative to the first conditioned sample.
An analytical apparatus, comprising:
- a membrane separator device adapted to treat a crude analyte-containing sample to pass the analyte through a membrane to form a first conditioned sample enriched in the analyte relative to the crude sample;
- a jet separator device fluidly coupled to the membrane separator to receive said first conditioned sample, and adapted to treat the first conditioned sample to form a second conditioned sample enriched in the analyte relative to the first conditioned sample;
- a
- a mass spectrometer having a sample input fluidly coupled to said jet separator device so as to receive said second conditioned sample for analysis.
The apparatus of claim 7, wherein said membrane device comprises a tubular membrane.
A device for treating a crude sample having an analyte contained in a liquid, comprising:
- a membrane separator device comprising a membrane against which the sample can be passed so as to selectively pass the analyte through the membrane and thus create a first conditioned sample enriched in the analyte relative to the crude sample;
- and
- a jet separator device comprising a sample delivery tube and a sample receiving tube separated by a gap and housed within a chamber adapted to be evacuated, said sample delivery tube being fluidly coupled to said membrane separator to receive said first conditioned sample, so that passage of said first conditioned sample through said delivery tube, across said gap and into said receiving tube forms a second conditioned sample enriched in the analyte relative to the first sample.
Dependencies are inferred from the claim text.