Methods for aiding periodontal tissue regeneration
AssigneeThe Procter & Gamble Company
InventorsNalinkant C. Damani, Douglas C. Mohl, Robert E. Singer, Jr.
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Abstract
Methods for aiding periodontal tissue regeneration with compositions containing bioresorbable polymers, leachable solvents, and bioavailable drug actives. The compositions useful for these methods are characterized by becoming harder upon contact with the periodontal tissue such that the composition is effective for aiding tissue regeneration and by releasing a therapeutically-effective amount of drug active agent.
Claims14
A method for aiding periodontal tissue regeneration in a human or lower animal, said method comprises placing at the site in need of periodontal tissue regeneration in a human or lower animal a composition comprising a bioresorbable polymer, leachable solvent, and bioavailable drug active agents, wherein said composition is further characterized by becoming harder upon contact with the periodontal tissue such that the composition is effective for aiding tissue regeneration, and by releasing a therapeutically-effective amount of drug active agent.
A method for aiding periodontal tissue regeneration in a human or lower animal, said method comprises placing at the site in need of periodontal tissue regeneration in a human or lower animal a composition comprising:
- (a) a bioresorbable polymer selected from the group consisting of polylactic acid, polyglycolic acid, and poly lactyl-co-glycolic acid;
- (b) leachable solvent selected from the group consisting of propylene carbonate, glyceryl triacetate, triethyl citrate, and mixtures thereof, and
- (c) bioavailable drug active agents, and wherein said composition is further characterized by becoming harder upon contact with the periodontal tissue such that the composition is effective for aiding tissue regeneration, and by releasing a therapeutically-effective amount of drug active agent.
A method for aiding periodontal tissue regeneration in a human or lower animal, said method comprises placing at the site in need of periodontal tissue regeneration in a human or lower animal a composition comprising:
- (a) from about 1% to about 90% bioresorbable polymer selected from poly lactyl-co-glycolic acid;
- (b) from about 0.1% to about 90% leachable solvent selected from the group consisting of propylene carbonate, glyceryl triacetate, triethyl citrate, and mixtures thereof, and
- (c) from about 0.1% to about 90% bioavailable drug active agents selected from the group consisting of antibacterial agents, antibiotics, anti-inflammatory agents, immune-suppressive agents, stimulatory agents, dentinal desensitizing agents, odor masking agents, immune reagents, local anesthetic agents, nutritional agents, antioxidants, lipopolysaccharide complexing agents, peroxides, growth factors, clot stabilizing factors, and mixtures thereof;
- and wherein said composition is further characterized by becoming harder upon contact with the periodontal tissue such that the composition is effective for aiding tissue regeneration, and by releasing a therapeutically-effective amount of drug active agent.
Dependencies are inferred from the claim text.