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US 5,446,070 AGranted
Compositions and methods for topical administration of pharmaceutically active agents
AssigneeNover Pharmaceuticals, Inc.
InventorJuan A. Mantelle
Life of this patent
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Abstract
Compositions for topical application comprising a therapeutically effective amount of a pharmaceutical agent(s), a pharmaceutically acceptable carrier, and a solvent for the pharmaceutical agent(s) in the carrier and methods of administering the pharmaceutical agents to a mammal are disclosed.
Claims45
A flexible, finite, bioadhesive composition for topical application comprising:
- (a) a therapeutically effective amount of at least one pharmaceutically active agent which is in solid form at ambient temperatures and pressures;
- (b) a pharmaceutically acceptable solvent for the pharmaceutically active agent, in an amount from about 5 to about 70 weight percent based on the weight of the whole composition, said solvent including about 5 to about 50 weight percent of a plasticizer;
- (c) in admixture with the pharmaceutically active agent in the solvent, a pharmaceutically acceptable polysaccharide bioadhesive carrier in an amount from about 20 to about 50 weight percent based on the weight of the whole composition;
- wherein the composition is substantially free of water, substantially water insoluble and is a bioadhesive;
- and wherein the pharmaceutically active agent is present in non-crystallized form in the composition.
2 more elements
A composition for topical application comprising:
- (a) a therapeutically effective amount of a first local anesthetic agent in base form;
- (b) a therapeutically effective amount of a different, second local anesthetic agent in non-salicylate acid-addition salt form;
- and
- (c) in an admixture with the anesthetic agents, a pharmaceutically acceptable carrier wherein the anesthetic agents comprise about 1 to about 50% by weight of the total composition.
1 more element
A composition for topical application comprising:
- (a) a therapeutically effective amount of a first local anesthetic agent in base form;
- (b) a therapeutically effective amount of a different, second local anesthetic agent in acid-addition salt form;
- and
- (c) in an admixture with the anesthetic agents, a pharmaceutically acceptable carrier which is substantially free of water
- wherein the anesthetic agents comprise about 1 to about 50% by weight of the total composition and wherein said composition is substantially free of water.
2 more elements
Dependencies are inferred from the claim text.