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US 5,444,106 AGranted
High refractive index silicone compositions
AssigneeKabi Pharmacia Ophthalmics, Inc.
InventorsStephen Q. Zhou, Jennifer C. Sy, Michelle A. Berteig, Thomas P. Richards
Life of this patent
Estimating the term…
Abstract
Organosiloxane compositions curable to optically clear, high refractive index elastomers are disclosed. The cured compositions have superior post-folding high resolution recovery making them suitable for fabricating foldable intraocular lenses used in small-incision ophthalmic surgeries. The organosiloxane compositions include first and second vinyl terminated organosiloxanes differing in molecular weights, each containing diphenylsiloxane and dimethylsiloxane, and, in addition, fumed silica, a crosslinking reagent, a platinum containing catalyst, and optionally an ultraviolet absorbing compound.
Claims22
A high refractive index, curable polyorganosiloxane composition useful for fabricating intraocular lenses, said composition comprising:
- about 30 wt. % to about 55 wt. % of a first vinyl terminated copolymer resin based on the total amount of the first and second vinyl terminated copolymer resins, said first vinyl terminated copolymer resin having about 80 mole % to about 95 mole % dimethylsiloxane and about 5 mole % to about 20 mole % diphenylsiloxane, said first vinyl terminated copolymer resin having a molecular weight sufficient to provide a first vinyl terminated copolymer resin viscosity of about 400 cps to about 2500 cps;
- about 45 wt. % to about 70 wt. % of a second vinyl terminated copolymer resin based on the total amount of the first and second vinyl terminated copolymer resins, said second vinyl terminated copolymer resin having about 80 mole % to about 95 mole % dimethylsiloxane and about 5 mole % to about 20 mole % diphenylsiloxane, said second vinyl terminated copolymer resin having a molecular weight sufficient to provide a second vinyl terminated copolymer resin viscosity of about 2500 cps to about 9500 cps;
- about 8 to about 25 parts of fumed silica filler per hundred parts resin;
- tetrakis(dimethylsiloxy) silane crosslinking reagent;
- and
- 2-[5-chloro-2H-benzotriazol-2-yl]-6-[1,1-dimethylethyl]-4-[2-propenyloxypro pyl]phenol hydrosilylated with tetrakis(dimethylsiloxy)silane.
3 more elements
A high refractive index, curable polyorganosiloxane composition useful for fabricating intraocular lenses, said composition comprising:
- about 30 wt. % to about 55 wt. % of a first vinyl terminated copolymer resin based on the total amount of the first and second vinyl terminated copolymer resins, said first vinyl terminated copolymer resin having about 80 mole % to about 95 mole % dimethylsiloxane and about 5 mole % to about 20 mole % diphenylsiloxane, said first vinyl terminated copolymer resin having a molecular weight sufficient to provide a first vinyl terminated copolymer resin viscosity of about 400 cps to about 2500 cps;
- about 45 wt. % to about 70 wt. % of a second vinyl terminated copolymer resin based on the total amount of the first and second vinyl terminated copolymer resins, said second vinyl terminated copolymer resin having about 80 mole % to about 95 mole % dimethylsiloxane and about 5 mole % to about 20 mole % diphenylsiloxane, said second vinyl terminated copolymer resin having a molecular weight sufficient to provide a second vinyl terminated copolymer resin viscosity of about 2500 cps to about 9500 cps;
- about 8 to about 25 parts of fumed silica filler per hundred parts resin;
- tetrakis(dimethylsiloxy) silane crosslinking reagent;
- and
- 2-[5-chloro-2H-benzotriazol-2-yl]-6-[1,1-dimethylethyl]-4-[2-propenyloxypro pyl]phenol hydrosilylated with a terpolymer of dimethylsiloxane, diphenylsiloxane, and methylhydrosiloxane.
3 more elements
A high refractive index, curable polyorganosiloxane composition useful for fabricating intraocular lenses, said composition comprising:
- about 42 wt. % to about 48 wt. % of a first vinyl terminated copolymer resin based on the total amount of the first and second vinyl terminated copolymer resins, said first vinyl terminated copolymer resin having about 82 mole % to about 88 mole % dimethylsiloxane and about 12 mole % to about 18 mole % diphenylsiloxane, said first vinyl terminated copolymer resin having a molecular weight sufficient to provide a first vinyl terminated copolymer resin viscosity of about 400 cps to about 1000 cps, and
- about 52 wt. % to about 58 wt. % of a second vinyl terminated copolymer resin based on the total amount of the first and second vinyl terminated copolymer resins, said second vinyl terminated copolymer resin having about 82 mole % to about 88 mole % dimethylsiloxane and about 12 mole % to about 18 mole % diphenylsiloxane, said second vinyl terminated copolymer resin having a molecular weight sufficient to provide a second vinyl terminated copolymer resin viscosity of about 4400 cps to about 5400 cps;
- about 8 to about 25 parts of fumed silica filler per hundred parts resin;
- tetrakis(dimethylsiloxy) silane crosslinking reagent;
- and
- 2-[5-chloro-2H-benzotriazol-2-yl]-611,1-dimethylethyl]-4-[2-propenyloxyprop yl]phenol hydrosilylated with tetrakis(dimethylsiloxy)silane.
3 more elements
A high refractive index, curable polyorganosiloxane composition useful for fabricating intraocular lenses, said composition comprising:
- about 42 wt. % to about 48 wt. % of a first vinyl terminated copolymer resin based on the total amount of the first and second vinyl terminated copolymer resins, said first vinyl terminated copolymer resin having about 82 mole % to about 88 mole % dimethylsiloxane and about 12 mole % to about 18 mole % diphenylsiloxane, said first vinyl terminated copolymer resin having a molecular weight sufficient to provide a first vinyl terminated copolymer resin viscosity of about 400 cps to about 1000 cps, and
- about 52 wt. % to about 58 wt. % of a second vinyl terminated copolymer resin based on the total amount of the first and second vinyl terminated copolymer resins, said second vinyl terminated copolymer resin having about 82 mole % to about 88 mole % dimethylsiloxane and about 12 mole % to about 18 mole % diphenylsiloxane, said second vinyl terminated copolymer resin having a molecular weight sufficient to provide a second vinyl terminated copolymer resin viscosity of about 4400 cps to about 5400 cps;
- about 8 to about 25 parts of fumed silica filler per hundred parts resin;
- tetrakis(dimethylsiloxy) silane crosslinking reagent;
- and
- 2-[5-chloro-2H-benzotriazol-2-yl]-6[1,1-dimethylethyl]-4-[2-propenyloxyprop yl]phenol hydrosilylated with a terpolymer of dimethylsiloxane, diphenylsiloxane, and methylhydrosiloxane.
3 more elements
A high refractive index, curable polyorganosiloxane composition useful for fabricating intraocular lenses, said composition consisting essentially of:
- about 42 wt. % to about 48 wt. % of a first vinyl terminated copolymer resin based on the total amount of the first and second vinyl terminated copolymer resins, said first vinyl terminated copolymer resin having about 82 mole % to about 88 mole % dimethylsiloxane and about 12 mole % to about 18 mole % diphenylsiloxane, said first vinyl terminated copolymer resin having a molecular weight sufficient to provide a first vinyl terminated copolymer resin viscosity of about 400 cps to about 1000 cps, and
- about 52 wt. % to about 58 wt. % of a second vinyl terminated copolymer resin based on the total amount of the first and second vinyl terminated copolymer resins, said second vinyl terminated copolymer resin having about 82 mole % to about 88 mole % dimethylsiloxane and about 12 mole % to about 18 mole % diphenylsiloxane, said second vinyl terminated copolymer resin having a molecular weight sufficient to provide a second vinyl terminated copolymer resin viscosity of about 4400 cps to about 5400 cps;
- about 11 to about 14 parts of fumed silica filler per hundred parts resin;
- about 5 to about 50 parts of platinum containing catalyst per million parts resin;
- about 1.5 to about 5 parts of tetrakis(dimethylsiloxy) silane crosslinking reagent per hundred parts resin;
- and
- about 0.1 to about 2 parts of 2-[5-chloro-2H-benzotriazol-2-yl]-6-[1,1-dimethylethyl]-4-[2-propenyloxypr opyl]phenol ultraviolet absorbing compound hydrosilylated with tetrakis(dimethylsiloxy) silane.
4 more elements
A high refractive index, curable polyorganosiloxane composition useful for fabricating intraocular lenses, said composition consisting essentially of:
- about 42 wt. % to about 48 wt. % of a first vinyl terminated copolymer resin based on the total amount of the first and second vinyl terminated copolymer resins, said first vinyl terminated copolymer resin having about 82 mole % to about 88 mole % dimethylsiloxane and about 12 mole % to about 18 mole % diphenylsiloxane, said first vinyl terminated copolymer resin having a molecular weight sufficient to provide a first vinyl terminated copolymer resin viscosity of about 400 cps to about 1000 cps, and
- about 52 wt. % to about 58 wt. % of a second vinyl terminated copolymer resin based on the total amount of the first and second vinyl terminated copolymer resins, said second vinyl terminated copolymer resin having about 82 mole % to about 88 mole % dimethylsiloxane and about 12 mole % to about 18 mole % diphenylsiloxane, said second vinyl terminated copolymer resin having a molecular weight sufficient to provide a second vinyl terminated copolymer resin viscosity of about 4400 cps to about 5400 cps;
- about 11 to about 14 parts of fumed silica filler per hundred parts resin;
- about 5 to about 50 parts of platinum containing catalyst per million parts resin;
- about 1.5 to about 5 parts of tetrakis(dimethylsiloxy)silane crosslinking reagent per hundred parts resin;
- and
- about 0.1 to about 2 parts of 2-[5-chloro-2H-benzotriazol-2-yl]-6-[1,1-dimethylethyl]-4-[2-propenyloxypr opyl]phenol ultraviolet absorbing compound hydrosilylated with a terpolymer of dimethylsiloxane, diphenylsiloxane, and methylhydrosiloxane.
4 more elements
Dependencies are inferred from the claim text.