Process to prepare leustroducsins
AssigneeSankyo Company, Limited
InventorsTakafumi Kohama, Isao Kaneko, Takemichi Nakamura, Takeshi Kagasaki, Ryuzo Enokita, Keiichi Matsuda
Life of this patent
Estimating the term…
Abstract
New compounds, which we have named the "Leustroducsins" have the formula (I): ##STR1## in which R represents a 5-methylhexanoyloxy group, a 6-methyloctanoyloxy group or a 7-methyloctanoyloxy group, and salts thereof, and may be prepared by fermentation using a microorganism of the genus Streptomyces, especially a strain of the species Streptomyces platensis, such as strain SANK 60191 (FERM BP-3288). These compounds may be used for the treatment or prophylaxis of: adverse reactions resulting from cancer chemotherapy or radiotherapy; infections; cancer; cerebral dysfunction; and fungal infections.
Claims10
A process for producing at least one leustroducsin of formula (I):
- ##STR4## in which R represents a 5-methylhexanoyloxy group, a 6-methyloctanoyloxy group or a 7-methyloctanoyloxy group, or a pharmaceutically acceptable salt thereof, which comprises cultivating a microorganism strain of the genus Strepmyces and the species platensis which produces said at least one leustroducsin of said formula (I), separating from the resultant culture said at least one leustroducsin of said formula (I) and purifying said at least one leustroducsin of said formula (I).
Dependencies are inferred from the claim text.