Technetium-99m labeled peptides for imaging
AssigneeDiatech, Inc.
InventorsRichard T. Dean, William McBride, Scott Buttram
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Abstract
The invention relates to radiolabeled imaging of a mammalian body. The invention in particular provides for reagents labeled with technetium-99m for such imaging. The invention provides peptides which bind Tc-99m and which can be targeted to specific sites within a mammalian body.
Claims8
A composition comprising a peptide reagent for preparing an imaging agent for imaging target sites within a mammalian body, wherein the peptide reagent is comprised of a peptide of between 4 and 100 amino acid residues that is covalently attached to a non-Tc-99m complexing Tc-99m complexing moiety comprising a single thiol group, and a stannous ion.
A method for radiolabeling a peptide reagent to prepare an imaging agent for imaging target sites within a mammalian body, wherein the reagent is comprised of a peptide of between 4 and 100 amino acid residues that is covalently attached to a non-Tc-99m complexed Tc-99m complexing moiety comprising a single thiol group, the method comprising reacting the peptide reagent with Tc-99m in the presence of a reducing agent.
Dependencies are inferred from the claim text.