Synthesis of tetraalkyl vinylidene diphosphonate monomer
AssigneeThe University of Tennessee Research Corporation
InventorSpiro D. Alexandratos
Life of this patent
Estimating the term…
Abstract
A method of making a monomer of tetraalkyl vinylidene-1, 1-diphosphonate. The monomer is manufactured by combining an aqueous secondary amine solution with a formaldehyde and a tetra (alkyl) methylene diphosphonate. The resulting mixture is maintained at a pH above about 6 and refluxed for two hours to enable reaction to produce the monomer of tetraalkyl vinylidene-1, 1-diphosphonate. The product monomer is then purified to produce the final end product.
Claims20
A method of making a tetraalkyl vinylidene-1, 1-diphosphonate, comprising the steps of:
- (a) combining a secondary amine, a formaldehyde and a tetra (alkyl) methylene diphosphonate to form a reaction mixture, wherein said tetra (alkyl) methylene diphosphonate comprises tetra (methyl) methylene diphosphonate, tetra (ethyl) methylene diphosphonate, tetra (propyl) methylene diphosphonate, tetra (isopropyl) methylene diphosphonate, and mixtures thereof;
- (b) adjusting the pH of said reaction mixture above about 6;
- and
- (c) heating said reaction mixture of step (b) for a sufficient time at a temperature of 50.degree. C. to 100.degree. C. for components of the reaction mixture to react and provide a reaction product comprising the tetraalkyl vinylidene-1, 1-diphosphonate.
A method of making a tetraalkyl vinylidene-1, 1-diphosphonate, comprising the steps of:
- (a) combining a secondary amine with water to form an aqueous amine solution;
- (b) admixing a formaldehyde and a tetra (alkyl) methylene diphosphonate with the aqueous amine solution to form an aqueous reaction solution, wherein said tetra (alkyl) methylene diphosphonate comprises tetra (methyl) methylene diphosphonate, tetra (ethyl) methylene diphosphonate, tetra (propyl) methylene diphosphonate, tetra (isopropyl) methylene diphosphonate, and mixtures thereof;
- (c) adjusting pH of the aqueous reaction solution to between about 6 and 14;
- (d) heating the aqueous reaction solution at a temperature of 50.degree. C. to 100.degree. C. for a sufficient time to form the tetraalkyl vinylidene-1, 1-diphosphonate;
- and
- (e) purifying the tetraalkyl vinylidene-1, 1-diphosphonate.
A method of making tetraalkyl vinylidene-1, 1-diphosphonate, comprising the steps of:
- (a) combining a secondary amine, a formalin and a tetra (alkyl) methylene diphosphonate to form a reaction mixture, wherein said tetra (alkyl) methylene diphosphonate comprises tetra (methyl) methylene diphosphonate, tetra (ethyl) methylene diphosphonate, tetra (propyl) methylene diphosphonate, tetra (isopropyl) methylene diphosphonate, and mixtures thereof;
- and
- (b) heating said reaction mixture at a temperature of 50.degree. C. to 100.degree. C. for a sufficient time to obtain a reaction product comprising the tetraalkyl vinylidene-1, 1-diphosphonate.
Dependencies are inferred from the claim text.