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AssigneeFidia S.p.A.
InventorsFrancesco della Valle, Aurelio Romeo, Silvana Lorenzi
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Two pharmaceutically useful fractions of hyaluronic acid are obtained comprising a first fraction with a molecular weight between 50,000 and 100,000 which is useful for wound healing, and a second fraction having a molecular weight between 500,000 and 730,000 which is useful for intraocular and intraarticular injections. In addition, pharmaceutical preparations for topical administration are provided containing a pharmacologically active substance together with hyaluronic acid or a molecular weight fraction thereof. The hyaluronic acid may be in the form of the free acid or may be a salt with an alkali or alkaline earth metal, magnesium, aluminum or ammonium, or in the form of a salt with one or more pharmacologically active substances.
A partial or a stoichiometrically neutral salt of hyaluronic acid or a molecular weight fraction thereof with at least one pharmacologically active substance of a basic nature suitable for topical administration.
A pharmaceutical composition which comprises as an active ingredient a pharmacologically effective amount of a partial or a stoichiometrically neutral salt of hyaluronic acid or a molecular weight fraction thereof with at least one pharmacologically active substance of a basic nature suitable for topical administration, with the proviso that said active substance is not capable of being absorbed intradermally or through the nasal or rectal mucosa.
A pharmaceutical composition which comprises hyaluronic acid or a pharmaceutically acceptable salt thereof and at least one pharmacologically active substance suitable for topical administration.
Dependencies are inferred from the claim text.