Peptide conjugate
AssigneeTakeda Chemical Industries, Ltd.
InventorsMakoto Fukuta, Satoshi Iinuma, Hiroaki Okada
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Abstract
The present invention provides a conjugate capable of passing the blood-brain barrier comprising a bioactive peptide or protein incapable of passing the blood-brain barrier and a carrier peptide which exhibits substantially no bioactivity and which is capable of passing the blood-brain barrier. The conjugate makes it possible to allow a bioactive peptide or protein incapable of passing the blood-brain barrier to easily pass the blood-brain barrier for uniform transport to the brain without any side effect of the carrier peptide.
Claims10
A peptide conjugate capable of passing the blood-brain barrier, comprising a bioactive peptide or protein incapable of passing the blood-brain barrier and an insulin fragment consisting essentially of:
- (a) a peptide chain having 14 to 21 amino acid residues from the N-terminus of insulin chain A and
- (b) another peptide chain having 16 to 22 amino acid residues from the N-terminus of insulin chain B.
Dependencies are inferred from the claim text.