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US 5,441,983 AGranted
Treatment of infection by enveloped virus with calix(N)arene compounds
AssigneeGenelabs Incorporated
InventorsKou M. Hwang, You M. Qi, Su-Ying Liu, William Choy, Jen Chen
Life of this patent
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Abstract
A method for inhibiting cell infection by an enveloped virus, by administering to an infection site, a therapeutically effective amount of a calix(n)arene compound derivatized, at its ring positions meta to the bridge attachements to the ring, with polar substitutent having a terminal carboxylate, phosphate, or sulfonate groups, including esters and amides which are cleavable in vivo. The compound may be administered orally, or topically, e.g., for treatment of herpes virus.
Claims16
A method of inhibiting infection of a mammalian cell by herpes simplex virus HSV-1 or HSV-2 comprising
- administering to the site of infection a therapeutically effective dose of a calix(n)arene compound which is derivatized, at its ring positions meta to the bridge attachments to the ring, with polar substituents having a terminal carboxylate, phosphonate, or sulfonate group.
Dependencies are inferred from the claim text.