Dry powder delivery system
AssigneesDuke University, Advanced Therapeutic Products, Inc.
InventorsJed E. Rose, Frederique Behm, James Turner
Life of this patent
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Abstract
A dry powder delivery system having an elongaged tube containing a matrix having a measured amount of dry particles of therapeutic compound and a porous element having a dessicant therein is disclosed. The porous element with the dessicant can be combined with the powder-containing matrix or the they can be two separate elements. The pressure drop induced by inhalation by the user causes air to flow through the tube and into contact with the particles of dry powder for discharging the particles for inhalation by the user.
Claims27
A dry powder delivery system, comprising:
- a) an elongated housing with proximal and distal ends and an air flow path between the ends;
- b) the distal end having at least one inlet opening through which air can be introduced into the flow path;
- c) the proximal end forming a mouthpiece with at least one outlet opening through which air can be withdrawn from the flow path;
- d) desiccant means for removing moisture from air in the flow path;
- e) means for introducing a measured amount of particles of a dry powder compound into the flow path, said dry powder being in communication with the desiccant means;
- and
- f) whereby suction created at the proximal end causes air to flow into the flow path and into contact with the particles of dry powder for discharging them through the outlet.
The delivery system of clam 1, wherein the distal end, desiccant means and means for introducing are combined in a cartridge, and the proximal end and elongated housing are combined into a mouthpiece in which the cartridge operatively fits.
A dry powder delivery system, comprising:
- a) an elongated housing with proximal and distal ends and an air flow path between the ends;
- b) the distal end having at least one inlet opening through which air can be introduced into the flow path;
- c) the proximal end forming a mouthpiece with at least one outlet opening through which air can be withdrawn from the flow path;
- d) means for introducing a measured amount of particles of a dry powder compound into the flow path, said means including a matrix of elongated fibers with passageways communicating with the flow path formed between the fibers, the dry powder being charged into the passageways;
- and
- e) whereby suction created at the proximal end causes air to flow into the flow path and into contact with the particles of dry powder for discharging them through the outlet.
A dry powder delivery system comprising:
- (a) an elongated tubular housing having proximal and distal ends and a passageway for air flow between the ends;
- (b) the distal end having at least one inlet opening through which air can be introduced into the passageway;
- (c) the proximal end forming a mouth piece with at least one outlet opening through which air can be withdrawn from the passageway;
- (d) resistance means for creating a relative pressure drop between the distal and proximal ends and a resistance to the drawing of air at the mouthpiece, said resistance being sufficiently great that the particles are drawn into the mouth of the user by simulating the action of puffing on a cigarette;
- (e) means for introducing a measured amount of particles of a dry powder compound having a therapeutic capability into air flowing in the passageway so that said particles will travel downstream from the resistance means whereby suction created at the proximal end causes air to flow in the passageway and into contact with particles of said dry powder for discharge through the outlet at a low velocity, said means for introducing including a matrix with a plurality of passageways in the flow path, the passageways containing the dry powder;
- (f) the particles being sized and coordinated with the pressure drop so the particles are deposited in the oral cavity and upper respiratory tract when drawn into the mouth of the user and inhaled.
Dependencies are inferred from the claim text.