Liquid polymer composition, and method of use
AssigneePerio Products Ltd.
InventorsMichael Friedman, Amnon Sintov
Life of this patent
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Abstract
The invention relates methods for the treatment of gingivitis, oral plaque and oral or dermatological fungal infections by the administration of a liquid methacrylic acid copolymer composition that contains a release adjusting agent and a pharmacological agent. The composition forms a solid film upon drying, and is capable of accomplishing the sustained release of the pharmacological agent such as to permit its use in the treatment or prevention of dental or dermatological conditions.
Claims14
A method of removing or inhibiting the buildup of oral plaque, said method comprising topical application of an efficacious amount of a liquid polymer composition to the teeth or gingival tissues of an animal or human, said liquid polymer composition consisting essentially of:
- (a) one or more sustained release acrylic polymers;
- (b) a bacteriocidal pharmacological agent;
- (c) a release adjusting agent selected from the group consisting of a cross-linking agent, citric acid, a sodium citrate, sodium docusate, and an amino acid;
- and
- (d) a pharmaceutically acceptable vehicle;
- wherein said sustained release acrylic polymers are selected from the group consisting of:
- (1) a methacrylic acid type A copolymer, an anionic copolymer based on methacrylic acid and methylmethacrylate wherein the ratio of free carboxyl groups to the ester groups is approximately 1:1;
- (2) a methacrylic acid type B copolymer, an anionic copolymern based on methacrylic acid and methylmethacrylate wherein the ratio of free carboxyl groups to the ester groups is approximately 1:2;
- (3) a dimethylaminoethylacrylate/ethylmethacrylate copolymer, a copolymer based on acrylic and methacrylic acid esters with a low content of quaternary ammonium groups wherein the molar ratio of the ammonium groups to the remaining neutral (meth)acrylic acid esters is 1:20;
- and
- (4) an ethyl methacrylate/chlorotrimethylammoniumethyl methacrylate copolymer, a copolymer based on acrylic and methacrylic acid esters with a low content of quaternary ammonium groups wherein the molar ratio of the ammonium groups to the remaining neutral (meth)acrylic acid esters is 1:40.
A method of treating gingivitis, comprising topical application of efficacious amounts of a liquid polymer composition to the teeth or gingival tissues of an animal or human., said liquid polymer composition consisting essentially of:
- (a) one or more sustained release acrylic polymers;
- (b) a bacteriocidal pharmacological agent;
- (c) a release adjusting agent selected from the group consisting of a cross-linking agent, citric acid, a sodium citrate, sodium ducosate, and an amino acid;
- and
- (d) a pharmaceutically acceptable vehicle;
- wherein said sustained release acrylic polymers are selected from the group consisting of:
- (1) a methacrylic acid type A copolymer, an anionic copolymer based on methacrylic acid and methylmethacrylate wherein the ratio of free carboxyl groups to the ester groups is approximately 1:1;
- (2) a methacrylic acid type B copolymer, an anionic copolymer based on methacrylic acid and methylmethacrylate wherein the ratio of free carboxyl groups to the ester groups is approximately 1:2;
- (3) a dimethylaminoethylacrylate/ethylmethacrylate copolymer, a copolymer based on acrylic and methacrylic acid esters with a low content of quaternary ammonium groups wherein the molar ratio of the ammonium groups to the remaining neutral (meth)acrylic acid esters is 1:20;
- and
- (4) an ethyl methacrylate/chlorotrimethylammoniumethyl methacrylate copolymer, a copolymer based on acrylic and methacrylic acid esters with a low content of quaternary ammonium groups wherein the molar ratio of the ammonium groups to the remaining neutral (meth)acrylic acid esters is 1:40.
Dependencies are inferred from the claim text.