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US 5,438,073 AGranted
Dermatological and/or cosmetological composition containing retinoids
AssigneePierre Fabre Cosmetique
InventorsJean-Hilaire Saurat, Georges Siegenthaler, Henri Cousse, Gilbert Mouzin, Yvon Gall
Life of this patent
Estimating the term…
Abstract
Dermatological and/or cosmetological compositions containing at least one retinoid of general formula (I), ##STR1## and the use of such compounds for preparing dermatological and/or cosmetological compositions.
Claims14
A dermatological and/or cosmetological composition comprising at least one retinoid of formula (I) ##STR13## in which:
- R.sub.1 and R.sub.2 independently represent ##STR14## or R.sub.1 and R.sub.2 together represent a double bond with a nitrogen atom so as to form an imine group of formula=N--R.sub.4,
- R.sub.3 represents a hydrogen atom, a hydroxyl group or an acyloxy group having 5 carbon atoms,
- R.sub.4 represents a group chosen from
- --CH.sub.2 --(CH.sub.2).sub.n --O--R.sub.5,
- or ##STR15## with n ranging from 0 to 5, R.sub.5 represents a hydrogen atom, or a lower alkyl group having 1 to 5 carbon atoms or a lower acyl group having 1 to 5 carbon atoms,
- R.sub.6 and R.sub.7 independently represent a hydrogen atom or a lower alkyl group having 1 to 5 carbon atoms, and
- R.sub.8 represents a hydrogen atom or a lower alkyl group having 1 to 5 carbon atoms.
4 more elements
A method of treating rosacea or seborrheic dermatitis comprising administering to a patient in need of such treatment a therapeutically effective amount of a retinoid of formula (I) ##STR21## in which:
- R.sub.1 and R.sub.2 independently represent ##STR22## or R.sub.1 and R.sub.2 together represent a double bond with an oxygen atom, or with a nitrogen atoms so as to form an imine group of formula=N--R.sub.4,
- R.sub.3 represents a hydrogen atom, a hydroxyl group or an acyloxy group having 5 carbon atoms,
- R.sub.4 represents a group chosen from:
- --CH.sub.2 --(CH.sub.2).sub.n --O--R.sub.5,
- or ##STR23## with n ranging from 0 to 5, R.sub.5 represents a hydrogen atom, a lower alkyl group having 1 to 5 carbon atoms or a lower acyl group having 1 to 5 carbon atoms,
- R.sub.6 and R.sub.7 independently represent a hydrogen atom or a lower alkyl group having 1 to 5 carbon atoms, and
- R.sub.8 represents a hydrogen atom or a lower alkyl group having 1 to 5 carbon atoms.
4 more elements
Dependencies are inferred from the claim text.