Oxygen carrying multiple emulsions
AssigneesIllinois Institute of Technology, Northfield Laboratories, Inc.
InventorsShuming Zheng, Richard L. Beissinger, Darsh T. Wasan, Lakshman R. Sehgal, Arthur L. Rosen
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Abstract
A process is provided wherein hemoglobin, a fragile material, is formulated into high hemoglobin content water-in-oil-in-water multiple emulsion while maintaining high yields and high oxygen exchange activity. A multiple emulsion of aqueous oxygen carrying material in oil in outer aqueous phase is suitable for provision of oxygen for oxygen transfer processes. A hemoglobin multiple emulsion in physiologically compatible oil in an outer aqueous saline solution is provided in sufficiently small droplet size to provide oxygen flow through blood vessels to desired body tissues or organs thereby providing a blood substitute.
Claims19
An oxygen containing multiple liquid emulsion comprising a primary emulsion comprising aqueous solution of oxygen carrying material in oil selected from the group consisting of vegetable oil, animal oil triglyceride and mixtures thereof, emulsified with a primary emulsifier having primary emulsion droplet sizes of up to about 5 microns and a secondary emulsion comprising said primary emulsion in an outer aqueous phase emulsified with a secondary emulsifier having secondary emulsion droplet sizes up to about 10 microns, said multiple emulsion having a viscosity of about 3 to about 9 cp, yield about 85 to about 99 percent, and oxygen carrying capacity about 7 to about 20 volume percent.
A blood substitute comprising a sterile oxygen carrying multiple emulsion comprising a primary emulsion comprising aqueous solution of oxygen carrying material in oil selected from the group consisting of vegetable oil, animal oil triglyceride and mixtures thereof, emulsified with a hydrophobic primary emulsifier having primary emulsion droplet sizes of up to about 5 microns and a secondary emulsion comprising said primary emulsion in an outer aqueous phase emulsified with a hydrophilic secondary emulsifier having secondary emulsion droplet sizes up to about 10 microns, said multiple emulsion having a viscosity of about 3 to about 9 cp, yield about 85 to about 99 percent, and oxygen carrying capacity about 7 to about 20 volume percent.
Dependencies are inferred from the claim text.