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US 5,436,265 AGranted
1-aroyl-3-indolyl alkanoic acids and derivatives thereof useful as anti-inflammatory agents
AssigneeMerck Frosst Canada, Inc.
InventorsCameron Black, Joseph A. Mancini, Cheuk K. Lau, Petpiboon Prasit, Philip J. Vickers
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Abstract
Compounds of the structures shown below are specific inhibitors of cyclooxygenase-2 useful in the treatment of cyclooxygenase-2 mediated disease states such as inflammation, pain and fever, and are non-ulcerogenic. ##STR1##
Claims8
A compound of structural formula:
- ##STR8## or a pharmaceutically acceptable salt thereof, wherein:
- R.sup.1 is --OCH.sub.3, --N(CH.sub.3).sub.2, --SCH.sub.3, --OCF.sub.3, halo or lower alkyl;
- R.sup.2 and R3 are independently H or lower alkyl or R.sup.2 and R3 may be joined to form a saturated hydrocarbon ring of 3 to 7 members;
- A is halogen, lower alkoxy, lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, CF.sub.3, CN, N.sub.3, NO.sub.2, SCF.sub.3 or OCF.sub.3 ;
- B is A;
- and
- C is A.
4 more elements
A compound which is ##STR10## wherein R.sup.1 is --F, --Cl, --CH(CH.sub.3).sub.2, --N(CH.sub.3).sub.2, --SCH.sub.3 or --OCF.sub.3.
Dependencies are inferred from the claim text.