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US 5,436,238 AGranted
Halichondrins and related compounds
AssigneePresident and Fellows of Harvard College
InventorsYoshito Kishi, Francis G. Fang, Craig J. Forsyth, Paul M. Scola, Suk K. Yoon
Life of this patent
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Abstract
Novel chemical compounds that can be used to synthesize halichondrin B and norhalichondrin B, and related derivatives. The total synthesis of halichondrin B and norhalichondrin B is also disclosed.
Claims11
A compound of the following structure:
- ##STR105## in which each of R.sub.1 and R.sub.2 is H- or C.sub.1-6 alkyl;
- and each of A and B is H-, HO- with or without an alcohol protecting group, an unsubstituted hydrocarbon, or a substituted hydrocarbon with or without an alcohol protecting group;
- wherein the total carbon number of A and B ranges from 0-18, not counting the carbons in any alcohol protecting groups, and said alcohol protecting group is R.sub.5 -O-, R.sub.5 -CO-O-, R.sub.5 -O-CO-O-, or ##STR106## R.sub.5 being C.sub.1-10 alkyl, C.sub.2-10 alkenyl, C.sub.2-10 alkynyl, C.sub.7-20 aralkyl, C.sub.7-20 alkaryl, phenyl or tetrahydropyranyl, and each of R.sub.6, R.sub.7 and R.sub.8 being C.sub.1-6 alkyl, C.sub.2-6 alkenyl or phenyl.
Dependencies are inferred from the claim text.