Artificial blood containing perfluoro chemicals in presence of emulsifying agents
AssigneeInternational Therapeutics Inc.
InventorsWalter B. Dandliker, W. Keith R. Watson, Thomas C. Drees
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Abstract
A blood substitute employs combinations of fluoro or perfluorochemicals capable in the presence of emulsifying agents of forming emulsions stable at room temperature and possessing enhanced oxygen carrying capacity; the invention enables preparation of an improved blood substitute, with improved O.sub.2 carrying capacity and stability, as well as lessened anaphylactoid reaction.
Claims8
An artificial blood comprising an emulsion of the following compound in water, said emulsion containing a non-toxic emulsifier and a synthetic phospholipid ##STR18##
An artificial blood comprising an emulsion of the compound ##STR19## in water, said emulsion containing a non-toxic emulsifier and a synthetic phospholipid, the amount of said compound being 10-60% by weight of the emulsion.
A synthetic blood having the following composition:
- ______________________________________ grams/100 ml ______________________________________ a) perfluoro hexamethylenetetramine 10-60 b) perfluoro [3,3,3] propellene 0.1-50 c) substance selected from the group about 3.0 consisting of:
- i) hydroxyethylstarch ii) polyvinyl pyrolidane iii) modified gelatin iv) dextran v) other equivalent polymer to supply colloidal osmotic (oncotic) pressure d) Pluronic F-68 fraction (or equivalent) about 2.7 e) Glycerin USP (Glycerol) about 0.8 (Optional) (if used) f) NaCl USP about 0.6 g) synthetic phospholipid 0.2 to 1.0 h) sodium bicarbonate about 0.21 i) Dextrose about 0.18 j) magnesium chloride.6H.sub.2 O about 0.043 k) calcium chloride.2H.sub.2 O about 0.036 l) potassium chloride about 0.034 m) water for injection qs. ______________________________________
Dependencies are inferred from the claim text.