Chemical compounds
AssigneeZeneca Limited
InventorsBrian R. Holloway, Ralph Howe, Balbir S. Rao
Life of this patent
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Abstract
Compounds of the formula (I): ##STR1## and bioprecursors and pharmaceutically acceptable salts thereof are described as .beta..sub.3 -adrenoceptor agonsists having anti-obesity, hypoglycaemic and related therapeutic utilities. Processes for their preparation are described as are compositions containing them.
Claims4
A method of treatment of disease conditions mediated through .beta..sub.3 -adrenoceptors by administering a pharmaceutically effective amount of a compound of the formula (I):
- ##STR22## or a bioprecursor or a pharmaceutically acceptable salt thereof to a patient in need thereof.
A method of stimulating thermogenesis and/or improving glucose tolerance by administering a pharmaceutically effective amount of a compound of the formula (I):
- ##STR23## or a bioprecursor or a pharmaceutically acceptable salt thereof to a patient in need thereof.
A method of treatment of obesity, mature onset diabetes, NIDDM, hypertension and/or hyperlipidaemia by administering a pharmaceutically effective amount of a compound of the formula (I):
- ##STR24## or a bioprecursor or a pharmaceutically acceptable salt thereof to a patient in need thereof.
A method of treatment of treatment of hypertriglyceridaemia, hypercholesterolaemia, atherosclerotic disease and conditions of low HDL levels by administering a pharmaceutically effective amount of a compound of the formula (I):
- ##STR25## or a bioprecursor or a pharmaceutically acceptable salt thereof to a patient in need thereof.
Dependencies are inferred from the claim text.