Chimeric CTLA4 receptor and methods for its use
AssigneeBristol-Myers Squibb Company
InventorsPeter S. Linsley, Jeffrey A. Ledbetter, Nitin K. Damle, William Brady
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Abstract
The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.
Claims8
A method for regulating functional CTLA4 positive T cell interactions with B7 positive cells comprising contacting said B7 positive cells with a B7 ligand to interfere with reaction of B7 antigen with CTLA4, wherein said B7 ligand is a fusion protein that contains a portion of the extracellular domain of CTLA4, which portion binds B7.
A method for treating immune system diseases mediated by T cell interactions with B7 positive cells comprising administering to a subject a B7 ligand to regulate T cell interactions with said B7 positive cells wherein said B7 ligand is a fusion protein that contains a portion of the extracellular domain of CTLA4, which portion binds B7.
Dependencies are inferred from the claim text.