Dispensing device containing a hydrophobic medium
AssigneePfizer Inc.
InventorAvinash G. Thombre
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Abstract
A device for the controlled delivery of an insoluble or partially aqueous insoluble beneficial agent to an aqueous containing environment. The device comprises a shaped wall that surrounds and defines an internal reservoir. The wall is formed at least in part of a sintered polymer microporous membrane permeable to a beneficial agent-containing hydrophobic medium when the wall is present in the aqueous containing environment. The reservoir contains a mixture of a hydrophilic swellable composition and a beneficial agent-containing hydrophobic medium.
Claims9
A device for controlled delivery of a beneficial agent to an aqueous containing environment, said device comprising:
- a shaped wall having a thickness of at least 100.mu.m that surrounds and defines an internal reservoir;
- said wall at least in part permeable to the aqueous environment and said wall formed at least in part of a sintered polymer microporous membrane permeable to a beneficial agent-containing hydrophobic medium when the wall is present in the aqueous containing environment, said sintered polymer impregnated with a low vapor pressure hydrophobic medium;
- and said reservoir containing a mixture of a hydrophilic swellable composition and said beneficial agent-containing hydrophobic medium, said beneficial agent being insoluble or partially insoluble in said aqueous containing environment.
A device for controlled delivery of a beneficial agent to an aqueous containing environment, said device comprising:
- a shaped wall having a thickness of at least 100.mu.m that surrounds and defines an internal reservoir;
- said wall at least in part permeable to the aqueous environment and said wall formed at least in part of a sintered polymer microporous membrane permeable to a beneficial agent-containing hydrophobic medium when the wall is present in the aqueous containing environment, said sintered polymer impregnated with hydrogel and wetted with a low vapor pressure hydrophobic medium;
- and said reservoir containing a mixture of a hydrophilic swellable composition and said beneficial agent-containing hydrophobic medium, said beneficial agent being insoluble or partially insoluble in said aqueous containing environment.
A device for controlled delivery of a beneficial agent to an aqueous containing environment, said device comprising:
- a shaped wall having a thickness of at least 100.mu.m that surrounds and defines an internal reservoir;
- said wall at least in part permeable to the aqueous environment and said wall formed at least in part of a sintered polymer microporous membrane, said sintered polymer impregnated with a hydrophilic hydrogel wetted with a hydrophilic medium and at least one hole provided therethrough;
- and said reservoir containing a mixture of a hydrophilic swellable composition and said beneficial agent-containing hydrophobic medium, said beneficial agent being insoluble or partially insoluble in said aqueous containing environment.
A device for controlled delivery of a beneficial agent to an aqueous containing environment, said device comprising:
- a shaped wall having a thickness of at least 100.mu.m that surrounds and defines an internal reservoir;
- said wall at least in part permeable to the aqueous environment and said wall formed at least in part of a material permeable to a beneficial agent-containing hydrophobic medium when the wall is present in the aqueous containing environment and said wall formed at least in part of a sintered polymer microporous membrane permeable to the aqueous containing environment, said sintered polymer impregnated with a low vapor pressure hydrophilic medium;
- and said reservoir containing a mixture of a hydrophilic swellable composition and said beneficial agent-containing hydrophobic medium, said beneficial agent being insoluble or partially insoluble in said aqueous containing environment.
A device for controlled delivery of a beneficial agent to an aqueous containing environment, said device comprising:
- a shaped wall having a thickness of at least 100.mu.m that surrounds and defines an internal reservoir;
- said wall at least in part permeable to the aqueous environment and said wall formed at least in part of a material permeable to a beneficial agent-containing hydrophobic medium when the wall is present in the aqueous containing environment and said wall formed at least in part of a sintered polymer microporous membrane permeable to the aqueous containing environment, said sintered polymer impregnated with a hydrogel and wetted with a low vapor pressure hydrophilic medium;
- and said reservoir containing a mixture of a hydrophilic swellable composition and said beneficial agent-containing hydrophobic medium, said beneficial agent being insoluble or partially insoluble in said aqueous containing environment.
A device for controlled delivery of a beneficial agent to an aqueous containing environment, said device comprising:
- a shaped wall having a thickness of at least 100 .mu.m that surrounds and defines an internal reservoir;
- said wall at least in part permeable to the aqueous environment and said wall formed at least in part of a material permeable to a beneficial agent-containing hydrophobic medium when the wall is present in the aqueous containing environment;
- and said reservoir containing sufficient air to achieve a predetermined time lag release and a mixture of a hydrophilic swellable composition and said beneficial agent-containing hydrophobic medium, said beneficial agent being insoluble or partially insoluble in said aqueous containing environment.
Dependencies are inferred from the claim text.