Stilbene derivatives as anticancer agents
AssigneeResearch Corporation Technologies, Inc.
InventorsMark S. Cushman, Ernest Hamel
Life of this patent
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Abstract
The present invention relates to stilbene derivatives which possess utility as anti-cancer agents. The compounds can be used to treat cancers which are susceptible to treatment therewith, and can be utilized in a method of treating such cancers. Pharmaceutical compositions containing the compounds are disclosed. Three preferred compounds among those disclosed are (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene, (Z)-1-(4-methylphenyl)-2-(3,4,5-trimethoxyphenyl)ethene, and 4-methyl-3',4',5'-trimethoxybenzylaniline hydrochloride.
Claims34
A compound of the formula:
- ##STR27## and pharmaceutically acceptable salts thereof wherein X is a cis ethylene radical of the formula:
- --(Y.sub.1)C.dbd.C(Z.sub.1);
- Y.sub.1 and Z.sub.1 are both hydrogen;
- R.sub.1, R.sub.5, R.sub.6 and R.sub.8 are independently H, halo, amino, lower alkylamino, diloweralkylamino, mercapto, lower alkylthio, amino lower alkyl, lower alkanoyl, nitro, CF.sub.3, amino lower alkoxy, lower alkylamino lower alkoxy, diloweralkylamino lower alkoxy,
- R.sub.2, R.sub.3 and R.sub.4 are lower alkoxy;
- R.sub.7 is lower alkoxy, amino, lower alkylamino, alkyl of 1-3 carbon atoms, diloweralkylamino, mercapto, lower alkylthio, amino lower alkyl, lower alkanoyl, nitro, CF.sub.3, amino lower alkoxy, lower alkylamino lower alkoxy, and diloweralkylamino lower alkoxy.
(E)-1-(4-N,N-dimethylamino)-2-(3,4,5-trimethoxyphenyl)ethene.
A pharmaceutical composition comprising a pharmaceutically effective amount of a compound of the formula:
- ##STR29## and pharmaceutically acceptable salts thereof wherein X is a cis ethylene radical of the formula:
- --(Y.sub.1)C.dbd.C(Z.sub.1);
- Y.sub.1 and Z.sub.1 are both hydrogen;
- R.sub.1, R.sub.5, R.sub.6 and R.sub.8 are independently H, halo, amino, lower alkylamino, diloweralkylamino, mercapto, lower alkylthio, amino lower alkyl, lower alkanoyl, nitro, CF.sub.3, amino lower alkoxy, lower alkylamino lower alkoxy, diloweralkylamino lower alkoxy,
- R.sub.2, R.sub.3 and R.sub.4 are lower alkoxy;
- R.sub.7 is lower alkoxy, amino, lower alkylamino, alkyl of 1-3 carbon atoms, diloweralkylamino, mercapto, lower alkylthio, amino lower alkyl, lower alkanoyl, nitro, CF.sub.3, amino lower alkoxy, lower alkylamino lower alkoxy, and diloweralkylamino lower alkoxy;
- and a pharmaceutical carrier therefor.
A pharmaceutical composition comprising a pharmaceutically effective amount of a (E)-1-(4-N,N-dimethylamino)-2-(3,4,5-trimethoxyphenyl)ethene and a pharmaceutical carrier therefor.
Dependencies are inferred from the claim text.