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US 5,430,031 AGranted
Serotoninergic ergoline derivatives
AssigneeFarmitalia Carlo Erba S.p.A.
InventorsSergio Mantegani, Enzo Brambilla, Carla Caccia, Nicola Carfagna
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Abstract
The present invention provides compounds of the formula (I) ##STR1## wherein A, R.sub.1, R.sub.2 and R.sub.3 are defined as in the specification, or a pharmaceutically acceptable salt thereof. A process for their preparation and the pharmacetical compositions comprising them are also provided.
Claims8
A compound of the formula (I) ##STR9## wherein A represents OH, NH.sub.2, COOR'.sub.3, OCONHR.sub.4, CONHR.sub.4, NHCOR.sub.4, NHCO.sub.2 R.sub.4, NHC(X)NHR.sub.4, NHC(X)NHCOR.sub.4, ##STR10## R.sub.1 is hydrogen or C.sub.1-4 linear or branched alkyl;
- R.sub.2 is hydrogen, chlorine, bromine or an S--C.sub.1-4 alkyl group;
- R.sub.3 and R.sub.3 ' are, independently, C.sub.1-5 alkyl or hydrogen, n is 0, 1 or 2, m is 1 or 2;
- R.sub.4 is hydrogen, C.sub.1-7 alkyl, C.sub.3-7 cycloalkyl, adamantidyl (tricyclo 3.3.1.1..sup.3,7) decan-1-yl, C.sub.1-5 -alkylphenyl, C.sub.2 -alkenyl-phenyl;
- C.sub.2 -alkynyl-phenyl, phenyl optionally substituted by one or more groups selected from C.sub.1-4 alkyl, C.sub.1-3 alkoxy, methylendioxy, cyano, trifluoromethyl, hydroxy, nitro and acetyl;
- a heterocyclic group selected from the group consisting of pyridyl, pyrazolyl, thiazolyl, pyrazinyl, pyrmidinyl, pyridazinyl, furyl and pyrrolyl, each of which is optionally substituted by a group selected from C.sub.1-4 alkyl, phenyl optionally substituted as defined above, C.sub.1-3 alkoxy and halogen;
- R.sub.5 is hydrogen, C.sub.1-4 alkyl or a phenyl group and X is NH, O, or S;
- or a pharmaceutically acceptable salt thereof.
4 more elements
Dependencies are inferred from the claim text.