Rotomelt granulation

A process for producing granules by rotomelt granulation comprising mixing at least one powdered pharmaceutically active material and a powdered excipient material with a higher melting point than said powdered pharmaceutically active material, in a zone wherein both powdered materials are maintained in a fluidized state by contacting said powdered materials with a rising stream of gas in an apparatus having a rapidly rotating horizontal-disk located within a vessel having a bottom surface and said rapidly rotating disk is located on the bottom surface of the vertical vessel wherein the gas is at a temperature sufficient to cause the powdered pharmaceutically active material to at least partially melt thereby causing said powdered pharmaceutically active material to aggregate with said powdered excipient material to form granules which are spherical.