Site specific synthesis of conjugated peptides
OwnerNahla Mensi-Fattohi, Christopher J. Molineaux +1inventors
InventorsNahla Mensi-Fattohi, Christopher J. Molineaux, Robert G. L. Shorr
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Abstract
Processes for synthesizing polypeptides containing substantially non-antigenic polymers, preferably poly(alkylene glycols) in specifically predetermined sites are disclosed. Polypeptides prepared by such processes acre also disclosed.
Claims29
A method of synthesizing a polypeptide containing a substantially non-antigenic polymer at one or more predetermined sites within said polypeptide, said method comprising:
- a) initiating synthesis of the amino acid chain of said polypeptide;
- b) conjugating a substantially non-antigenic polymer to a facilitator moiety;
- c) introducing said conjugated polymer at each point in the synthesis which corresponds to each said predetermined site;
- and
- d) continuing said synthesis of said amino acid chain of said polypeptide.
A method of synthesizing a polypeptide containing a substantially non-antigenic polymer at one or more predetermined sites within said polypeptide, said method comprising:
- a) initiating synthesis of the amino acid chain of said polypeptide;
- b) introducing a blocked facilitator moiety at that point in the synthesis that corresponds to each said predetermined site;
- c) completing the synthesis of said amino acid chain of said polypeptide;
- and
- d) deblocking and conjugating the facilitator moiety with said non-antigenic polymer.
Dependencies are inferred from the claim text.